SCHEMBL1040140

SCHEMBL1040140

COc1ccc(C(c2ccccc2)(c2ccc(OC)cc2)C(N)CCCCCN)cc1

nearest known ligand 0.57

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 13/20 0.57
KCNH2 Q12809 1/20 0.57
SLC7A5 Q01650 6/20 0.46
ALDH1A1 P00352 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3475085 1.00 KIF11 (0.57) KIF11KCNH2SLC7A5ALDH1A1
SCHEMBL529077 0.87 KIF11 (0.46) KIF11SLC7A5
SCHEMBL27914480 0.87 KIF11 (0.46) KIF11SLC7A5
SCHEMBL5023008 0.85 KIF11 (0.56) KIF11KCNH2SLC7A5ALDH1A1
SCHEMBL21931379 0.82 KIF11 (0.54) KIF11KCNH2ALDH1A1
Acetic Acid SCHEMBL30066547 0.81 CPB2 (0.41) KIF11
SCHEMBL31217761 0.80 KIF11 (0.67) KIF11KCNH2
SCHEMBL2390381 0.80 HRH1 (0.50) KIF11KCNH2
SCHEMBL29060869 0.77 KIF11 (0.88) KIF11KCNH2
SCHEMBL29864858 0.76 KIF11 (0.55) KIF11KCNH2SLC7A5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10240189-B2 Solid support assay systems and methods utilizing non-standard bases LUMINEX CORPORATION (US) 2019-03-26 US disclosed
US-9611509-B2 Materials and methods for detection of nucleic acids LUMINEX CORPORATION (US) 2017-04-04 US disclosed
US-20150132759-A1 SOLID SUPPORT ASSAY SYSTEMS AND METHODS UTILIZING NON-STANDARD BASES LUMINEX CORP (US) 2015-05-14 US disclosed
US-8969047-B2 Solid support assay systems and methods utilizing non-standard bases LUMINEX CORPORATION (US) 2015-03-03 US disclosed
US-20140057269-A1 Materials and Methods for Detection of Nucleic Acids LUMINEX CORPORATION (US) 2014-02-27 US disclosed
US-20140024550-A1 Solid Support Assay Systems and Methods Utilizing Non-Standard Bases LUMINEX CORPORATION (US) 2014-01-23 US disclosed
US-8518671-B2 Solid support assay systems and methods utilizing non-standard bases LUMINEX CORPORATION (US) 2013-08-27 US disclosed
US-8519117-B2 Materials and methods for detection of nucleic acids LUMINEX CORPORATION (US) 2013-08-27 US disclosed
US-20120295808-A1 Solid Support Assay Systems and Methods Utilizing Non-Standard Bases GRENIER JENNIFER K (US) 2012-11-22 US disclosed
US-8217160-B2 Determining which allele is present in a sample tot reduce non-specific hybridization or reduce the impact of non-specific hybridization on the assay by using oligonucleotides having at least on non-standard base (iscytosine and isoguanine); kits ERAGEN BIOSCIENCES, INC. (US) 2012-07-10 US disclosed
US-7422850-B2 Materials and methods for detection of nucleic acids ERAGEN BIOSCIENCES, INC. (US) 2008-09-09 US disclosed
US-20070087361-A1 Solid support assay systems and methods utilizing non-standard bases ERAGEN BIOSCIENCES, INC. 2007-04-19 US disclosed
US-20070031885-A1 Materials and methods for detection of nucleic acids ERAGEN BIOSCIENCES, INC. 2007-02-08 US disclosed
US-20060252091-A1 Materials and methods for detection of nucleic acids ERAGEN BIOSCIENCES, INC. 2006-11-09 US disclosed
US-20060078936-A1 Solid support assay systems and methods utilizing non-standard bases ERAGEN BIOSCIENCES, INC. 2006-04-13 US disclosed
US-6977161-B2 Solid support assay systems and methods utilizing non-standard bases ERAGEN BIOSCIENCES, INC. (US) 2005-12-20 US disclosed
US-20040106108-A1 Solid support assay systems and methods utilizing non-standard bases ERAGEN BIOSCIENCES, INC. (US) 2004-06-03 US disclosed
EP-1358352-A2 SOLID SUPPORT ASSAY SYSTEMS AND METHODS UTILIZING NON-STANDARD BASES Eragen Biosciences, Inc. (US) 2003-11-05 EP disclosed
US-20020150900-A1 Materials and methods for detection of nucleic acids LUMINEX CORPORATION 2002-10-17 US disclosed
WO-2002033126-A2 SOLID SUPPORT ASSAY SYSTEMS AND METHODS UTILIZING NON-STANDARD BASES ERAGEN BIOSCIENCES, INC. (US) 2002-04-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070031885-A1 Materials and methods for detection of nucleic acids POLRMT, RNGTT, ADAR KIF11 4200/4885KCNH2 4509/4885SLC7A5 4258/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.