Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 13/20 | 1.00 |
| ▸ | GSK3A | P49840 | 8/20 | 1.00 |
| ▸ | HTT | P42858 | 5/20 | 1.00 |
| ▸ | NPC1 | O15118 | 3/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 2/20 | 1.00 |
| ▸ | RAB9A | P51151 | 2/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 1.00 |
| ▸ | EGFR | P00533 | 1/20 | 0.82 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.74 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.74 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.74 |
| ▸ | POLB | P06746 | 1/20 | 0.72 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.71 |
| ▸ | CDK1 | P06493 | 1/20 | 0.71 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.71 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16157157 | 0.94 | GSK3B (0.89) | GSK3BGSK3AHTTNPC1ALDH1A1 | |
| SCHEMBL14604409 | 0.93 | GSK3B (1.00) | GSK3BGSK3AHTTNPC1ALDH1A1 | |
| SCHEMBL16944477 | 0.92 | GSK3B (0.85) | GSK3BGSK3AHTTNPC1ALDH1A1 | |
| SCHEMBL928258 | 0.91 | EGFR (1.00) | GSK3BGSK3AHTTNPC1ALDH1A1 | |
| SCHEMBL14603763 | 0.89 | GSK3B (0.80) | GSK3BGSK3AHTTNPC1ALDH1A1 | |
| SCHEMBL16944450 | 0.88 | GSK3B (0.78) | GSK3BGSK3AHTTNPC1ALDH1A1 | |
| SCHEMBL16157074 | 0.88 | EGFR (0.94) | GSK3BGSK3AHTTNPC1ALDH1A1 | |
| SCHEMBL16944463 | 0.87 | RAB9A (0.79) | GSK3BGSK3AHTTNPC1ALDH1A1 | |
| SCHEMBL5024100 | 0.87 | GSK3B (1.00) | GSK3BGSK3AHTTNPC1ALDH1A1 | |
| SCHEMBL16157177 | 0.85 | GSK3B (1.00) | GSK3BGSK3AHTTNPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111568903-A | Application of bioactive molecule and derivative thereof in preparation of HIV-1 expression inhibitor | 中山大学 | 2020-08-25 | — | — | CN | claimed |
| CN-111568903-A | Application of bioactive molecule and derivative thereof in preparation of HIV-1 expression inhibitor | 中山大学 | 2020-08-25 | — | — | CN | disclosed |
| CN-111568903-A | Application of bioactive molecule and derivative thereof in preparation of HIV-1 expression inhibitor | 中山大学 | 2020-08-25 | — | — | CN | disclosed |
| US-20200140425-A1 | COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | MASSACHUSETTS GENERAL HOSPITAL | 2020-05-07 | — | — | US | disclosed |
| US-10301294-B2 | Compounds for the treatment of tuberculosis | The Broad Institute Inc. (US) | 2019-05-28 | — | — | US | disclosed |
| US-9669014-B2 | Small molecule inhibitors of superoxide dismutase expression | NORTHWESTERN UNIVERSITY (US) | 2017-06-06 | — | — | US | disclosed |
| US-9669014-B2 | Small molecule inhibitors of superoxide dismutase expression | NORTHWESTERN UNIVERSITY (US) | 2017-06-06 | — | — | US | disclosed |
| US-20160214969-A1 | SMALL MOLECULE INHIBITORS OF SUPEROXIDE DISMUTASE EXPRESSION | NORTHWESTERN UNIVERSITY (US) | 2016-07-28 | — | — | US | disclosed |
| US-20160214969-A1 | SMALL MOLECULE INHIBITORS OF SUPEROXIDE DISMUTASE EXPRESSION | NORTHWESTERN UNIVERSITY (US) | 2016-07-28 | — | — | US | disclosed |
| US-20160031870-A1 | COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | NIH - DEITR | 2016-02-04 | — | — | US | disclosed |
| US-20160031870-A1 | COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | NIH - DEITR | 2016-02-04 | — | — | US | disclosed |
| US-20150210679-A1 | SMALL MOLECULE INHIBITORS OF SUPEROXIDE DISMUTASE EXPRESSION | NORTHWESTERN UNIVERSITY (US) | 2015-07-30 | — | — | US | disclosed |
| US-20150210679-A1 | SMALL MOLECULE INHIBITORS OF SUPEROXIDE DISMUTASE EXPRESSION | NORTHWESTERN UNIVERSITY (US) | 2015-07-30 | — | — | US | disclosed |
| WO-2014165090-A1 | COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | THE BROAD INSTITUTE, INC. (US) | 2014-10-09 | — | — | WO | disclosed |
| US-8492378-B2 | GSK-3β inhibitor | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-07-23 | — | — | US | disclosed |
| WO-2013007663-A1 | 2-BENZYLSULFANYL[1,3,4]-OXADIAZOLE DERIVATIVES, AND MEDICAL USE THEREOF | Technische Universität Darmstadt (DE) | 2013-01-17 | — | — | WO | disclosed |
| WO-2012065065-A9 | METHODS AND COMPOSITIONS FOR MODULATING HAIR GROWTH, WOUND HEALING AND SCAR REVISION | FOLLICA, INC. (US) | 2012-10-11 | — | — | WO | disclosed |
| WO-2012065065-A1 | METHODS AND COMPOSITIONS FOR MODULATING HAIR GROWTH, WOUND HEALING AND SCAR REVISION | FOLLICA, INC. (US) | 2012-05-18 | — | — | WO | disclosed |
| US-20100069381-A1 | GSK-3BETAINHIBITOR | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160214969-A1 | SMALL MOLECULE INHIBITORS OF SUPEROXIDE DISMUTASE EXPRESSION | SOD1, SOD3, CAT | GSK3B 2605/4885GSK3A 2565/4885HTT 723/4885 |
| US-10301294-B2 | Compounds for the treatment of tuberculosis | GOT2, G6PD, FNTB | GSK3B 2519/4885GSK3A 2959/4885HTT 4103/4885 |
| US-20200140425-A1 | COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | GOT2, G6PD, FNTB | GSK3B 2519/4885GSK3A 2959/4885HTT 4103/4885 |
| US-20100069381-A1 | GSK-3BETAINHIBITOR | GSK3B, GSK3A, GSKIP | GSK3B 1/4885GSK3A 2/4885HTT 3480/4885 |
| US-20150210679-A1 | SMALL MOLECULE INHIBITORS OF SUPEROXIDE DISMUTASE EXPRESSION | SOD1, SOD3, CAT | GSK3B 2605/4885GSK3A 2565/4885HTT 723/4885 |
| US-20160031870-A1 | COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | GOT2, G6PD, FNTB | GSK3B 2519/4885GSK3A 2959/4885HTT 4103/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.