Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13201260 | 0.85 | LMNA (0.42) | LMNANPC1RAB9AKDM4ENFKB1 | |
| SCHEMBL5023260 | 0.75 | HTR2A (0.46) | — | |
| SCHEMBL13201225 | 0.72 | FPR3 (0.42) | LMNANPC1SMN1; SMN2HTTALDH1A1 | |
| SCHEMBL5023849 | 0.72 | LMNA (0.40) | LMNANPC1RAB9AKDM4ENFKB1 | |
| SCHEMBL5023358 | 0.70 | NAMPT (0.37) | NPC1SMN1; SMN2ALDH1A1GAANAMPT | |
| SCHEMBL13201258 | 0.70 | HTR2C (0.40) | — | |
| SCHEMBL13200902 | 0.70 | HTR2C (0.40) | — | |
| SCHEMBL13888191 | 0.70 | HTR2C (0.40) | — | |
| SCHEMBL6398857 | 0.69 | L3MBTL1 (0.68) | NPC1KDM4ESMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL13201242 | 0.69 | FPR3 (0.40) | LMNANPC1SMN1; SMN2L3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1632483-B1 | HETEROCYCLIC SUBSTITUTED CARBONYL DERIVATIVES AND THEIR USE AS DOPAMINE D3 RECEPTOR LIGANDS | AVENTIS PHARMA INC (US) | 2008-10-29 | — | — | EP | claimed |