Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | FPR3 | P25089 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5023358 | 0.79 | NAMPT (0.37) | NPC1SMN1; SMN2ALDH1A1GAANAMPT | |
| SCHEMBL5016836 | 0.76 | L3MBTL1 (0.36) | LMNANPC1KDM4ESMN1; SMN2MAPK1 | |
| SCHEMBL13201260 | 0.75 | LMNA (0.42) | LMNARAB9ANPC1KDM4ENFKB1 | |
| SCHEMBL5025688 | 0.72 | LMNA (0.43) | LMNARAB9ANPC1KDM4ENFKB1 | |
| SCHEMBL5022622 | 0.66 | MEN1 (0.38) | LMNAKDM4ESMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL13201225 | 0.66 | FPR3 (0.42) | LMNANPC1SMN1; SMN2HTTALDH1A1 | |
| SCHEMBL13201270 | 0.64 | SMN1; SMN2 (0.43) | LMNARAB9ANPC1KDM4ENFKB1 | |
| SCHEMBL13201242 | 0.63 | FPR3 (0.40) | LMNANPC1SMN1; SMN2GAAPOLB | |
| SCHEMBL15190251 | 0.62 | ALDH1A1 (0.56) | LMNARAB9ANPC1KDM4ESMN1; SMN2 | |
| SCHEMBL5023775 | 0.61 | DRD2 (0.37) | RAB9ANPC1DRD3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1632483-B1 | HETEROCYCLIC SUBSTITUTED CARBONYL DERIVATIVES AND THEIR USE AS DOPAMINE D3 RECEPTOR LIGANDS | AVENTIS PHARMA INC (US) | 2008-10-29 | — | — | EP | claimed |