Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 8/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5028541 | 0.85 | BACE1 (0.56) | BACE1CYP1A2CYP2C19CYP2C9CYP3A4 | |
| Trifluoroacetic Acid SCHEMBL4995659 | 0.81 | BACE1 (0.53) | BACE1MEN1KMT2AORAI1TP53 | |
| SCHEMBL5030034 | 0.78 | HCAR3 (0.35) | MEN1KMT2AMAPTORAI1UTS2R | |
| SCHEMBL5026581 | 0.77 | MAPT (0.34) | BACE1MEN1KMT2AMAPTORAI1 | |
| SCHEMBL8234637 | 0.76 | BACE1 (0.43) | BACE1 | |
| SCHEMBL5030127 | 0.71 | BACE1 (0.36) | BACE1KMT2AUTS2RCYP1A2CYP2D6 | |
| SCHEMBL5024092 | 0.69 | NOS3 (0.41) | MEN1KMT2AMAPT | |
| SCHEMBL5024194 | 0.69 | CYP1A2 (0.33) | MEN1KMT2ACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL5025605 | 0.68 | MAPT (0.36) | MEN1KMT2AMAPTORAI1CYP1A2 | |
| SCHEMBL18064339 | 0.68 | TAAR1 (0.49) | MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957462-A2 | NOVEL 2-AMINO-HETEROCYCLES UDEFUL IN THE TREATMENT OF ABETA-RELATED PATHOLOGIES | Astra Zeneca AB (SE) | 2008-08-20 | — | — | EP | claimed |
| WO-2007058583-A2 | NOVEL 2-AMINO-HETEROCYCLES USEFUL IN THE TREATMENT OF ABETA-RELATED PATHOLOGIES | ASTRAZENECA AB (SE) | 2007-05-24 | — | — | WO | claimed |
| EP-1957462-A2 | NOVEL 2-AMINO-HETEROCYCLES UDEFUL IN THE TREATMENT OF ABETA-RELATED PATHOLOGIES | Astra Zeneca AB (SE) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007058583-A2 | NOVEL 2-AMINO-HETEROCYCLES USEFUL IN THE TREATMENT OF ABETA-RELATED PATHOLOGIES | ASTRAZENECA AB (SE) | 2007-05-24 | — | — | WO | disclosed |