Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 4/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | CCR6 | P51684 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5026484 | 0.88 | NOS3 (0.41) | NOS3HDAC4MAPTNOS2 | |
| SCHEMBL5025594 | 0.82 | LMNA (0.40) | NOS3PDE5ATSHRALDH1A1LMNA | |
| Trifluoroacetic Acid SCHEMBL5001990 | 0.78 | NOS3 (0.60) | NOS3KDM1AHDAC4NOS2 | |
| SCHEMBL5030034 | 0.72 | HCAR3 (0.35) | MAPTGAASMN1; SMN2MEN1KMT2A | |
| SCHEMBL5026581 | 0.71 | MAPT (0.34) | MAPTGAASMN1; SMN2MEN1KMT2A | |
| SCHEMBL5005082 | 0.71 | NOS3 (0.71) | NOS3KDM1ANOS2 | |
| Trifluoroacetic Acid SCHEMBL5095021 | 0.69 | NOS2 (0.42) | NOS3KDM1AHDAC4MAPTNOS2 | |
| SCHEMBL5026434 | 0.69 | BACE1 (0.41) | MAPTMEN1KMT2A | |
| Trifluoroacetic Acid SCHEMBL5005119 | 0.65 | NOS3 (0.61) | NOS3NOS2 | |
| Trifluoroacetic Acid SCHEMBL5001834 | 0.65 | NOS2 (0.60) | NOS3KDM1AHDAC4NOS2PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957462-A2 | NOVEL 2-AMINO-HETEROCYCLES UDEFUL IN THE TREATMENT OF ABETA-RELATED PATHOLOGIES | Astra Zeneca AB (SE) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007058583-A2 | NOVEL 2-AMINO-HETEROCYCLES USEFUL IN THE TREATMENT OF ABETA-RELATED PATHOLOGIES | ASTRAZENECA AB (SE) | 2007-05-24 | — | — | WO | disclosed |