Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.32 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.32 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.32 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.31 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.30 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5024194 | 0.88 | CYP1A2 (0.33) | GAASMN1; SMN2MEN1KMT2ACYP1A2 | |
| SCHEMBL5030034 | 0.87 | HCAR3 (0.35) | MAPTGAASMN1; SMN2UTS2RMEN1 | |
| SCHEMBL5028464 | 0.83 | LMNA (0.40) | SMN1; SMN2MEN1KMT2ABACE1CYP1A2 | |
| Trifluoroacetic Acid SCHEMBL5007666 | 0.78 | BACE1 (0.36) | MAPTGAASMN1; SMN2UTS2RMEN1 | |
| SCHEMBL5026434 | 0.77 | BACE1 (0.41) | MAPTUTS2RMEN1KMT2ABACE1 | |
| SCHEMBL8234440 | 0.76 | UTS2R (0.38) | MAPTGAASMN1; SMN2UTS2RBACE1 | |
| SCHEMBL5025605 | 0.75 | MAPT (0.36) | MAPTGAASMN1; SMN2MEN1KMT2A | |
| SCHEMBL5030127 | 0.74 | BACE1 (0.36) | GAAUTS2RKMT2ABACE1CYP1A2 | |
| SCHEMBL2086622 | 0.73 | BACE1 (0.39) | BACE1PDK2 | |
| SCHEMBL5024092 | 0.71 | NOS3 (0.41) | MAPTGAASMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957462-A2 | NOVEL 2-AMINO-HETEROCYCLES UDEFUL IN THE TREATMENT OF ABETA-RELATED PATHOLOGIES | Astra Zeneca AB (SE) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007058583-A2 | NOVEL 2-AMINO-HETEROCYCLES USEFUL IN THE TREATMENT OF ABETA-RELATED PATHOLOGIES | ASTRAZENECA AB (SE) | 2007-05-24 | — | — | WO | disclosed |