Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 4/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.36 |
| ▸ | MMP1 | P03956 | 2/20 | 0.36 |
| ▸ | MMP2 | P08253 | 2/20 | 0.36 |
| ▸ | MMP3 | P08254 | 2/20 | 0.36 |
| ▸ | MMP9 | P14780 | 2/20 | 0.36 |
| ▸ | MMP13 | P45452 | 2/20 | 0.36 |
| ▸ | MMP14 | P50281 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | BMP1 | P13497 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5031172 | 0.85 | KEAP1 (0.36) | KEAP1MEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL5928370 | 0.82 | ACR (0.42) | SMN1; SMN2LMNAPOLB | |
| SCHEMBL7456019 | 0.79 | PTGER1 (0.41) | PTGER1KEAP1MEN1KMT2AMAPT | |
| SCHEMBL7257359 | 0.79 | MAPT (0.43) | PTGER1KEAP1MEN1KMT2AMAPT | |
| SCHEMBL7455250 | 0.77 | ADAM17 (0.37) | MEN1KMT2AMAPTMMP1MMP2 | |
| SCHEMBL5982918 | 0.77 | POLB (0.44) | PTGER1KEAP1MEN1KMT2AMAPT | |
| SCHEMBL2581362 | 0.77 | KEAP1 (0.47) | KEAP1NFE2L2BMP1 | |
| SCHEMBL8370091 | 0.77 | KEAP1 (0.45) | KEAP1MEN1KMT2ANFE2L2 | |
| SCHEMBL5691171 | 0.76 | ALDH1A1 (0.35) | KEAP1MEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL5928586 | 0.75 | MMP2 (0.40) | KEAP1MEN1KMT2AMAPTNFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080118969-A1 | BIS-AMINO ACID HYDROXYETHYLAMINO SULFONAMIDE RETROVIRAL PROTEASE INHIBITORS | G.D. SEARLE LLC (US) | 2008-05-22 | — | — | US | disclosed |
| US-6861539-B1 | Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors | G. D. SEARLE & CO. (US) | 2005-03-01 | — | — | US | disclosed |
| EP-1188766-A1 | Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors | G.D. Searle & Co. (US) | 2002-03-20 | — | — | EP | disclosed |
| US-6143788-A | ENZYME INHIBITORS | G.D. SEARLE & CO. (US) | 2000-11-07 | — | — | US | disclosed |