Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1624359 | 1.00 | LMNA (0.36) | LMNATSHRBCHEACHECTSL | |
| SCHEMBL5117022 | 1.00 | LMNA (0.36) | LMNATSHRBCHEACHECTSL | |
| SCHEMBL17008624 | 0.81 | FFAR4 (0.43) | LMNAEPHX2SCN9A | |
| SCHEMBL18279743 | 0.81 | FFAR4 (0.43) | LMNAEPHX2SCN9A | |
| SCHEMBL1623867 | 0.80 | LMNA (0.37) | LMNATSHRBCHEACHECTSL | |
| SCHEMBL1623869 | 0.80 | LMNA (0.37) | LMNATSHRBCHEACHECTSL | |
| SCHEMBL28738071 | 0.77 | TSHR (0.42) | LMNATSHRBCHEACHECTSL | |
| SCHEMBL18279737 | 0.77 | CPB1 (0.42) | LMNATSHRACHEEPHX2 | |
| SCHEMBL23851449 | 0.75 | TSHR (0.47) | LMNATSHRBCHEACHECTSL | |
| SCHEMBL17008259 | 0.75 | PKM (0.41) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1902031-A1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | Merck Frosst Canada Ltd. (CA) | 2008-03-26 | — | — | EP | disclosed |
| WO-2007003056-A1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2007-01-11 | — | — | WO | disclosed |