Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.34 |
| ▸ | GBA1 | P04062 | 2/20 | 0.34 |
| ▸ | UGCG | Q16739 | 2/20 | 0.34 |
| ▸ | GBA2 | Q9HCG7 | 2/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1623867 | 1.00 | LMNA (0.37) | LMNATSHRBCHEACHESCN9A | |
| SCHEMBL1624002 | 0.84 | LMNA (0.37) | LMNATSHRSCN9ATACR1CTSL | |
| SCHEMBL1624004 | 0.84 | LMNA (0.37) | LMNATSHRSCN9ATACR1CTSL | |
| SCHEMBL1625947 | 0.82 | LMNA (0.39) | LMNATSHRTACR1CTSLCTSB | |
| SCHEMBL18279743 | 0.82 | FFAR4 (0.43) | LMNASCN9AFFAR4EPHX2 | |
| SCHEMBL17008624 | 0.82 | FFAR4 (0.43) | LMNASCN9AFFAR4EPHX2 | |
| SCHEMBL1625944 | 0.82 | LMNA (0.39) | LMNATSHRTACR1CTSLCTSB | |
| SCHEMBL5117022 | 0.80 | LMNA (0.36) | LMNATSHRBCHEACHESCN9A | |
| SCHEMBL1624359 | 0.80 | LMNA (0.36) | LMNATSHRBCHEACHESCN9A | |
| SCHEMBL5026595 | 0.80 | LMNA (0.36) | LMNATSHRBCHEACHESCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7928091-B2 | Cathepsin cysteine protease inhibitors | MERCK FROSST CANADA LTD. (CA) | 2011-04-19 | — | — | US | disclosed |
| US-20090093444-A1 | Cathepsin Cysteine Protease Inhibitors | MERCK FROSST CANADA LTD. (CA) | 2009-04-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090093444-A1 | Cathepsin Cysteine Protease Inhibitors | CTSB, CTSS, CTSZ | LMNA 2431/4885TSHR 3675/4885BCHE 493/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.