Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA2D1 | P54289 | 3/20 | 0.63 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.63 |
| ▸ | CACNB1 | Q02641 | 3/20 | 0.63 |
| ▸ | CACNA1C | Q13936 | 3/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.60 |
| ▸ | MEN1 | O00255 | 5/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.60 |
| ▸ | ATM | Q13315 | 1/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.56 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.56 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1691475 | 0.85 | SLC6A9 (0.74) | CACNA2D1CACNA1BCACNB1CACNA1CKMT2A | |
| SCHEMBL10930361 | 0.83 | CACNA2D1 (0.65) | CACNA2D1CACNA1BCACNB1CACNA1CKMT2A | |
| SCHEMBL678935 | 0.82 | KMT2A (0.57) | KMT2AMEN1ATMGAAHTT | |
| SCHEMBL4388744 | 0.81 | ALDH1A1 (0.60) | KMT2AMEN1NPSR1ATMLMNA | |
| SCHEMBL10979461 | 0.80 | CACNA2D1 (0.58) | CACNA2D1CACNA1BCACNB1CACNA1CKMT2A | |
| SCHEMBL4400416 | 0.79 | SIGMAR1 (0.48) | CACNA2D1CACNA1BCACNB1KMT2AMEN1 | |
| SCHEMBL14859945 | 0.79 | LMNA (0.75) | CACNA2D1CACNA1BCACNB1CACNA1CKMT2A | |
| SCHEMBL7278476 | 0.79 | MEN1 (0.61) | CACNA2D1CACNA1BCACNB1CACNA1CKMT2A | |
| Hydrochloric Acid SCHEMBL10981330 | 0.79 | CACNA2D1 (0.56) | CACNA2D1CACNA1BCACNB1CACNA1CKMT2A | |
| SCHEMBL4148742 | 0.79 | KMT2A (0.59) | CACNA2D1CACNA1BCACNB1CACNA1CKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871372-A1 | COMBINATION THERAPY COMPRISING AN N-TYPE CALCIUM CHANNEL BLOCKER FOR THE ALLEVIATION OF PAIN | Neuromed Pharmaceuticals, Ltd. (CA) | 2008-01-02 | — | — | EP | claimed |
| WO-2006105670-A1 | COMBINATION THERAPY COMPRISING AN N-TYPE CALCIUM CHANNEL BLOCKER FOR THE ALLEVIATION OF PAIN | NEUROMED PHARMACEUTICALS LTD. (CA) | 2006-10-12 | — | — | WO | claimed |
| CN-103491964-A | Solid dispersion formulations and methods of use thereof | ZALICUS PHARMACEUTICALS LTD | 2014-01-01 | — | — | CN | disclosed |
| EP-2654726-A1 | SOLID DISPERSION FORMULATIONS AND METHODS OF USE THEREOF | Zalicus Pharmaceuticals Ltd. (CA) | 2013-10-30 | — | — | EP | disclosed |
| EP-2654726-A1 | SOLID DISPERSION FORMULATIONS AND METHODS OF USE THEREOF | Zalicus Pharmaceuticals Ltd. (CA) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012122279-A1 | SOLID DISPERSION FORMULATIONS AND METHODS OF USE THEREOF | ZALICUS PHARMACEUTICALS LTD. (CA) | 2012-09-13 | — | — | WO | disclosed |
| WO-2012122279-A1 | SOLID DISPERSION FORMULATIONS AND METHODS OF USE THEREOF | ZALICUS PHARMACEUTICALS LTD. (CA) | 2012-09-13 | — | — | WO | disclosed |
| WO-2012122274-A1 | SELF-EMULSIFYING FORMULATIONS AND METHODS OF USE THEREOF | ZALICUS PHARMACEUTICALS LTD. (CA) | 2012-09-13 | — | — | WO | disclosed |