Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3551350 | 0.81 | HSD11B1 (0.41) | SMN1; SMN2MEN1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL5027626 | 0.81 | HSD11B1 (0.36) | SMN1; SMN2MEN1TP53KMT2AALDH1A1 | |
| SCHEMBL5031157 | 0.79 | HSD11B1 (0.42) | GAASMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL30635290 | 0.76 | HSD11B1 (0.46) | MEN1KMT2ALMNA | |
| SCHEMBL22720076 | 0.76 | GAA (0.47) | GAAMAPK1SMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL5031123 | 0.75 | GAA (0.50) | GAAMAPK1SMN1; SMN2CA12CA1 | |
| SCHEMBL28543459 | 0.73 | MEN1 (0.43) | GAASMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL7176021 | 0.73 | MEN1 (0.43) | GAASMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL24680905 | 0.73 | GAA (0.45) | GAAMAPK1SMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL4562587 | 0.72 | RBP4 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7429609-B2 | Pyrazole compound and medicinal composition containing the same | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2008-09-30 | — | — | US | disclosed |
| EP-1510516-A1 | PYRAZOLE COMPOUND AND MEDICINAL COMPOSITION CONTAINING THE SAME | Eisai Co., Ltd. (JP) | 2005-03-02 | — | — | EP | disclosed |