Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.47 |
| ▸ | CDK9 | P50750 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 4/20 | 0.44 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9373869 | 0.79 | RECQL (0.66) | RIPK1MAPTSMN1; SMN2LMNAMAPK1 | |
| SCHEMBL1465733 | 0.77 | MEN1 (0.41) | MAPTSMN1; SMN2LMNARECQLPOLB | |
| SCHEMBL28632584 | 0.77 | RECQL (0.47) | RIPK1MAPTSMN1; SMN2LMNAMAPK1 | |
| SCHEMBL14294847 | 0.76 | MAPT (0.69) | RIPK1MAPTSMN1; SMN2LMNAMAPK1 | |
| SCHEMBL9507998 | 0.75 | MAPT (0.54) | RIPK1MAPTSMN1; SMN2LMNAMAPK1 | |
| SCHEMBL10489384 | 0.73 | KAT2B (0.74) | RIPK1MAPTSMN1; SMN2LMNAMAPK1 | |
| SCHEMBL5718688 | 0.73 | ALDH1A1 (0.50) | MAPTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL12742256 | 0.73 | ALDH1A1 (0.53) | MAPTSMN1; SMN2LMNAPOLBALDH1A1 | |
| SCHEMBL27510433 | 0.73 | HTT (0.57) | MAPTSMN1; SMN2LMNAMAPK1PKM | |
| SCHEMBL29306545 | 0.72 | HCAR3 (0.67) | RIPK1MAPTSMN1; SMN2LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007756-A2 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | Vertex Pharmceuticals Incorporated (US) | 2008-12-31 | — | — | EP | disclosed |
| WO-2007117715-A2 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-10-18 | — | — | WO | disclosed |