SCHEMBL503186

SCHEMBL503186

N[C@@H](CSc1cccs1)C(=O)O

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 10/20 0.52
MMP1 P03956 3/20 0.44
FCER2 P06734 2/20 0.44
MAPT P10636 1/20 0.43
HPGD P15428 1/20 0.43
CYP2C19 P33261 1/20 0.42
NPC1 O15118 1/20 0.41
RAB9A P51151 1/20 0.41
PTGER1 P34995 1/20 0.41
PTGFR P43088 1/20 0.41
PTGER3 P43115 1/20 0.41
PTGER2 P43116 1/20 0.41
SLC1A3 P43003 1/20 0.41
SLC1A2 P43004 1/20 0.41
SLC1A1 P43005 1/20 0.41
ALPI P09923 1/20 0.41
PKM P14618 1/20 0.41
PTGS1 P23219 1/20 0.41
XIAP P98170 1/20 0.41
SLC7A5 Q01650 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7350753 1.00 KIF11 (0.52) KIF11MMP1FCER2MAPTHPGD
SCHEMBL7442311 0.81 NPC1 (0.46) KIF11MMP1FCER2MAPTHPGD
SCHEMBL7442301 0.81 NPC1 (0.46) KIF11MMP1FCER2MAPTHPGD
SCHEMBL4573064 0.76 MMP1 (0.50) MMP1FCER2MAPTHPGDCYP2C19
SCHEMBL4573057 0.76 MMP1 (0.50) MMP1FCER2MAPTHPGDCYP2C19
SCHEMBL6282249 0.75 PTGER1 (0.51) MMP1FCER2MAPTHPGDCYP2C19
SCHEMBL20393464 0.75 MMP1 (0.48) MMP1FCER2MAPTHPGDNPC1
SCHEMBL7247505 0.75 MAOA (0.50) MMP1FCER2MAPTHPGDNPC1
SCHEMBL11386082 0.74 KMT2A (0.58) KIF11MAPTHPGDCYP2C19NPC1
SCHEMBL11386091 0.74 KMT2A (0.58) KIF11MAPTHPGDCYP2C19NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 76 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105264064-B O-phosphoserine export proteins and methods of producing O-phosphoserine using the same CJ第一制糖株式会社 2020-08-18 CN claimed
EP-3348567-B1 NOVEL O-PHOSPHOSERINE EFFLUX PROTEIN VARIANT AND METHOD FOR PRODUCING O-PHOSPHOSERINE, CYSTEINE AND DERIVATIVE THEREOF USING SAME CJ CHEILJEDANG CORP (KR) 2020-08-05 EP claimed
EP-3181685-B1 O-PHOSPHOSERINE PRODUCING MICROORGANISM AND METHOD FOR PRODUCING O-PHOSPHOSERINE OR L-CYSTEINE USING SAME CJ CHEILJEDANG CORP (KR) 2019-08-14 EP claimed
US-12529082-B2 O-phosphoserine export protein variant and method for producing O-phosphoserine, cysteine, and derivatives thereof using the same CJ CHEILJEDANG CORPORATION (KR) 2026-01-20 US disclosed
US-20250376493-A1 NOVEL YhhS VARIANT AND METHOD FOR PRODUCING O-PHOSPHOSERINE, CYSTEINE, AND DERIVATE OF CYSTEINE USING SAME CJ CHEILJEDANG CORPORATION (KR) 2025-12-11 US disclosed
US-20250075221-A1 O-PHOSPHOSERINE-PRODUCING MICROORGANISM AND METHOD FOR PRODUCING O-PHOSPHOSERINE OR L-CYSTEINE USING THE SAME CJ CHEILJEDANG CORPORATION (KR) 2025-03-06 US disclosed
CN-118786220-A Microorganism producing O-phosphoserine and method for producing O-phosphoserine or L-cysteine using the same CJ第一制糖株式会社 2024-10-15 CN disclosed
US-20240294955-A1 RECOMBINANT MICROORGANISM IN WHICH EXPRESSION OF NADH:QUINONE OXIDOREDUCTASE IS CONTROLLED, AND METHOD FOR PRODUCING O-PHOSPHOSERINE, CYSTEINE, AND DERIVATIVE THEREOF BY USING SAME CJ CHEILJEDANG CORPORATION (KR) 2024-09-05 US disclosed
US-20240287559-A1 NOVEL MdtH VARIANT AND METHOD FOR PRODUCING O-PHOSPHOSERINE, CYSTEINE, AND DERIVATIVE OF CYSTEINE USING SAME CJ CHEILJEDANG CORPORATION (KR) 2024-08-29 US disclosed
EP-4368632-A1 NOVEL YHHS VARIANT AND METHOD FOR PRODUCING O-PHOSPHOSERINE, CYSTEINE, AND DERIVATE OF CYSTEINE USING SAME CJ CheilJedang Corporation (KR) 2024-05-15 EP disclosed
CN-117980321-A Novel MdtH variants and methods of using the same to produce O-phosphoserine, cysteine, and cysteine derivatives CJ第一制糖株式会社 2024-05-03 CN disclosed
US-20150218538-A1 Methods and Compositions for Modulating G-Alpha-Q Signaling NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2015-08-06 US disclosed
US-8445678-B2 2-quinoxalinol salen compounds and uses thereof AUBURN UNIVERSITY (US) 2013-05-21 US disclosed
WO-2013029648-A1 NEW AMINOACID COMPOUNDS FOR TREATING TUMOURS AND AUTOIMMUNE DISEASES ARKE' ORGANICS S.R.L. (IT) 2013-03-07 WO disclosed
US-20120028362-A1 2-QUINOXALINOL SALEN COMPOUNDS AND USES THEREOF AUBURN UNIVERSITY (US) 2012-02-02 US disclosed
US-20090286968-A1 2-Quinoxalinol Salen Compounds and Uses Thereof AUBURN UNIVERSITY (US) 2009-11-19 US disclosed
US-5672615-A MATRIX-DEGRADING METALLOPROTEINASE INHIBITORS NOVARTIS CORPORATION (US) 1997-09-30 US disclosed
US-5646167-A ADMINISTERED AS METALLOPROTEINASE INHIBITOR, ANTITUMOR OR ANTICARCINOGENIC AGENT CIBA-GEIGY CORPORATION (US) 1997-07-08 US disclosed
WO-1996040101-A1 CERTAIN ARYLSULFONAMIDO-SUBSTITUTED HYDROXAMIC ACIDS FOR THE TREATMENT OF CERTAIN TUMORS NOVARTIS AG (CH) 1996-12-19 WO disclosed
US-5552419-A METALLOPROTEINASE INHIBITORS CIBA-GEIGY CORPORATION (US) 1996-09-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090286968-A1 2-Quinoxalinol Salen Compounds and Uses Thereof NQO1, NQO2, SQOR KIF11 3663/4885MMP1 4818/4885FCER2 4512/4885
US-20120028362-A1 2-QUINOXALINOL SALEN COMPOUNDS AND USES THEREOF NQO1, NQO2, SQOR KIF11 3663/4885MMP1 4818/4885FCER2 4512/4885
US-12529082-B2 O-phosphoserine export protein variant and method for producing O-phosphoserine, cysteine, and derivatives thereof using the same PSPH, PHAX, MARS1 KIF11 716/4885MMP1 2371/4885FCER2 4837/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.