Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 16/20 | 0.41 |
| ▸ | MMP1 | P03956 | 14/20 | 0.41 |
| ▸ | MMP13 | P45452 | 9/20 | 0.41 |
| ▸ | MMP9 | P14780 | 9/20 | 0.41 |
| ▸ | MMP8 | P22894 | 5/20 | 0.41 |
| ▸ | MMP3 | P08254 | 10/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.39 |
| ▸ | PLA2G7 | Q13093 | 2/20 | 0.36 |
| ▸ | MMP7 | P09237 | 2/20 | 0.35 |
| ▸ | MMP14 | P50281 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5033281 | 1.00 | MMP2 (0.41) | MMP2MMP1MMP13MMP9MMP8 | |
| SCHEMBL7424768 | 0.76 | PLA2G7 (0.34) | MMP2MMP1MMP13MMP9MMP8 | |
| SCHEMBL16096222 | 0.75 | ALDH1A1 (0.41) | — | |
| SCHEMBL16096223 | 0.75 | ALDH1A1 (0.41) | — | |
| SCHEMBL7221727 | 0.74 | MMP2 (0.37) | MMP2MMP1MMP13MMP9MMP8 | |
| SCHEMBL7368800 | 0.73 | MMP1 (0.37) | MMP2MMP1MMP13MMP9MMP8 | |
| SCHEMBL7078769 | 0.73 | MMP2 (0.36) | MMP2MMP1MMP13MMP9MMP8 | |
| SCHEMBL7078766 | 0.72 | MMP2 (0.36) | MMP2MMP1MMP13MMP9MMP8 | |
| SCHEMBL7603860 | 0.71 | PLA2G7 (0.40) | MMP2MMP1MMP13MMP9MMP8 | |
| SCHEMBL5033284 | 0.71 | CYP2D6 (0.31) | PLA2G7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1918278-A1 | Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases | Novartis AG (CH) | 2008-05-07 | — | — | EP | disclosed |
| US-6410580-B1 | ANTIINFLAMMATORY AGENTS, RHEUMATIC DISEASES | NOVARTIS AG (CH) | 2002-06-25 | — | — | US | disclosed |
| US-6277987-B1 | FOR INHIBITING MATRIX-DEGRADING METALLOPROTEINASES IN MAMMALS | NOVARTIS AG (CH) | 2001-08-21 | — | — | US | disclosed |