Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G7 | Q13093 | 2/20 | 0.34 |
| ▸ | MMP2 | P08253 | 13/20 | 0.34 |
| ▸ | MMP1 | P03956 | 12/20 | 0.34 |
| ▸ | MMP13 | P45452 | 9/20 | 0.34 |
| ▸ | MMP9 | P14780 | 8/20 | 0.34 |
| ▸ | MMP8 | P22894 | 5/20 | 0.34 |
| ▸ | MMP3 | P08254 | 10/20 | 0.33 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | MMP7 | P09237 | 2/20 | 0.32 |
| ▸ | MMP14 | P50281 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7426955 | 1.00 | PLA2G7 (0.34) | PLA2G7MMP2MMP1MMP13MMP9 | |
| SCHEMBL5033281 | 0.76 | MMP2 (0.41) | PLA2G7MMP2MMP1MMP13MMP9 | |
| SCHEMBL5033280 | 0.76 | MMP2 (0.41) | PLA2G7MMP2MMP1MMP13MMP9 | |
| SCHEMBL7423437 | 0.71 | MMP2 (0.41) | MMP2MMP1MMP13MMP9MMP8 | |
| SCHEMBL7425111 | 0.67 | ALDH1A1 (0.42) | MMP2MMP9 | |
| SCHEMBL8282174 | 0.64 | MMP2 (0.45) | PLA2G7MMP2MMP1MMP13MMP9 | |
| SCHEMBL7040815 | 0.63 | PLA2G7 (0.50) | PLA2G7MMP2MMP1MMP13MMP9 | |
| SCHEMBL20534578 | 0.62 | CHRNB2 (0.36) | — | |
| SCHEMBL419379 | 0.61 | F2 (0.48) | PLA2G7MMP2MMP1MMP13MMP9 | |
| SCHEMBL7508132 | 0.61 | RAB9A (0.43) | PLA2G7MMP2MMP1MMP13MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1053226-A1 | SULFONYLAMINO DERIVATIVES WHICH INHIBIT MATRIX-DEGRADING METALLOPROTEINASES | Novartis AG (CH) | 2000-11-22 | — | — | EP | disclosed |
| WO-1999042443-A1 | SULFONYLAMINO DERIVATIVES WHICH INHIBIT MATRIX-DEGRADING METALLOPROTEINASES | NOVARTIS AG (CH) | 1999-08-26 | — | — | WO | disclosed |