Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 5/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.38 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.38 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5035193 | 0.87 | HPGD (0.47) | CYP3A4HPGDKMT2AMEN1PPARG | |
| SCHEMBL5032542 | 0.87 | HPGD (0.42) | CYP3A4HPGDKMT2AMEN1PPARG | |
| SCHEMBL5038720 | 0.81 | CNR1 (0.45) | CNR1 | |
| SCHEMBL5034874 | 0.79 | HPGD (0.42) | CYP3A4HPGDPPARGNCOA2NCOA1 | |
| SCHEMBL5034838 | 0.79 | LMNA (0.46) | CYP3A4HPGDKMT2AMEN1PPARG | |
| SCHEMBL5035256 | 0.78 | KMT2A (0.41) | HPGDKMT2AMEN1CYP1A2CYP2C9 | |
| SCHEMBL5035234 | 0.77 | ALDH1A1 (0.41) | CYP3A4HPGDKMT2AMEN1PPARG | |
| SCHEMBL5034720 | 0.76 | HSD11B1 (0.46) | CYP3A4HPGDPPARGNCOA2NCOA1 | |
| SCHEMBL5032621 | 0.75 | CYP3A4 (0.53) | CYP3A4HPGDPPARGNCOA2NCOA1 | |
| SCHEMBL5034926 | 0.74 | LIPE (0.46) | CYP3A4CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1694673-B1 | THIAZOLE DERIVATES | HOFFMANN LA ROCHE (CH) | 2008-01-16 | — | — | EP | disclosed |