SCHEMBL5036645

SCHEMBL5036645

N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC(O)[C@H]1C(=O)O

nearest known ligand 0.40

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ TACR1 P25103 1/20 0.40
▸ DPP4 P27487 14/20 0.38
▸ DPP8 Q6V1X1 6/20 0.38
▸ DPP9 Q86TI2 6/20 0.38
▸ DPP7 Q9UHL4 4/20 0.34
▸ FAP Q12884 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4595206 0.81 DPP4 (0.44) DPP4DPP8DPP9DPP7FAP
SCHEMBL5734357 0.81 DPP4 (0.44) DPP4DPP8DPP9DPP7FAP
SCHEMBL4595209 0.81 DPP4 (0.44) DPP4DPP8DPP9DPP7FAP
SCHEMBL4440457 0.78 ATM (0.39) DPP4DPP8DPP9
SCHEMBL4440451 0.78 ATM (0.39) DPP4DPP8DPP9
SCHEMBL7831182 0.78 DPP7 (0.41) DPP4DPP8DPP9DPP7
SCHEMBL8200272 0.78 DPP7 (0.41) DPP4DPP8DPP9DPP7
SCHEMBL7759104 0.78 DPP4 (0.42) DPP4DPP8DPP9DPP7FAP
SCHEMBL10454951 0.78 TRHR (0.43) DPP4DPP8DPP9
SCHEMBL7759091 0.78 DPP4 (0.42) DPP4DPP8DPP9DPP7FAP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070078096-A1 Buffered drug formulations for transdermal electrotransport delivery CORMIER MICHEL J 2007-04-05 — — US claimed
US-20050171021-A1 Buffered drug formulations for transdermal CORMIER MICHEL J (US) 2005-08-04 — — US claimed
EP-1028706-B1 BUFFERED DRUG FORMULATIONS FOR TRANSDERMAL ELECTROTRANSPORT DELIVERY ALZA CORP (US) 2003-07-09 — — EP claimed
US-20020058608-A1 BUFFERED DRUG FORMULATIONS FOR TRANSDERMAL ELECTROTRANSPORT DELIVERY ALZA CORPORATION 2002-05-16 — — US claimed
EP-1028706-A1 BUFFERED DRUG FORMULATIONS FOR TRANSDERMAL ELECTROTRANSPORT DELIVERY ALZA CORPORATION (US) 2000-08-23 — — EP claimed
WO-1999024015-A1 BUFFERED DRUG FORMULATIONS FOR TRANSDERMAL ELECTROTRANSPORT DELIVERY ALZA CORPORATION (US) 1999-05-20 — — WO claimed
EP-1689489-B1 PEPTIDICALLY BUFFERED FORMULATIONS FOR ELECTROTRANSPORT APPLICATIONS AND METHODS OF MAKING ALZA CORP (US) 2008-02-27 — — EP disclosed
US-20070249988-A1 Electrotransport Delivery of Nesiritide ALZA CORPORATION (US) 2007-10-25 — — US disclosed
US-20070078096-A1 Buffered drug formulations for transdermal electrotransport delivery CORMIER MICHEL J 2007-04-05 — — US disclosed
EP-1689489-A1 PEPTIDICALLY BUFFERED FORMULATIONS FOR ELECTROTRANSPORT APPLICATIONS AND METHODS OF MAKING Alza Corporation (US) 2006-08-16 — — EP disclosed
US-20050171021-A1 Buffered drug formulations for transdermal CORMIER MICHEL J (US) 2005-08-04 — — US disclosed
US-20050142531-A1 Peptidically buffered formulations for electrotransport applications and methods of making ALZA CORPORATION 2005-06-30 — — US disclosed
WO-2005051485-A1 PEPTIDICALLY BUFFERED FORMULATIONS FOR ELECTROTRANSPORT APPLICATIONS AND METHODS OF MAKING ALZA CORPORATION (US) 2005-06-09 — — WO disclosed
EP-1028706-B1 BUFFERED DRUG FORMULATIONS FOR TRANSDERMAL ELECTROTRANSPORT DELIVERY ALZA CORP (US) 2003-07-09 — — EP disclosed
US-20020058608-A1 BUFFERED DRUG FORMULATIONS FOR TRANSDERMAL ELECTROTRANSPORT DELIVERY ALZA CORPORATION 2002-05-16 — — US disclosed
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