Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 4/20 | 0.44 |
| ▸ | MMP2 | P08253 | 2/20 | 0.44 |
| ▸ | MMP3 | P08254 | 2/20 | 0.44 |
| ▸ | MMP9 | P14780 | 2/20 | 0.44 |
| ▸ | TPSAB1 | Q15661 | 3/20 | 0.43 |
| ▸ | TPSD1 | Q9BZJ3 | 3/20 | 0.43 |
| ▸ | TPSG1 | Q9NRR2 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 4/20 | 0.41 |
| ▸ | CA12 | O43570 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1380169 | 0.89 | MMP2 (0.48) | MMP13MMP2MMP3MMP9HPGD | |
| SCHEMBL1376755 | 0.84 | KMT2A (0.47) | MMP13MMP2MMP3MMP9HPGD | |
| SCHEMBL1376946 | 0.84 | RAB9A (0.50) | MMP13MMP2MMP3MMP9HPGD | |
| SCHEMBL1380239 | 0.83 | MMP2 (0.45) | MMP13MMP2MMP3MMP9HPGD | |
| Hydroxyamine SCHEMBL7481959 | 0.82 | MMP2 (0.44) | MMP13MMP2MMP3MMP9HPGD | |
| SCHEMBL1378426 | 0.81 | MMP2 (0.50) | MMP13MMP2MMP3MMP9CA9 | |
| SCHEMBL5031626 | 0.80 | MMP2 (0.49) | MMP13MMP2MMP3MMP9CA9 | |
| SCHEMBL5034745 | 0.80 | TPSAB1 (0.55) | MMP13MMP2MMP3MMP9TPSAB1 | |
| SCHEMBL1381142 | 0.79 | MMP2 (0.41) | MMP13MMP2MMP3MMP9HPGD | |
| SCHEMBL3718689 | 0.78 | MMP2 (0.53) | MMP13MMP2MMP3MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1918278-A1 | Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases | Novartis AG (CH) | 2008-05-07 | — | — | EP | disclosed |
| US-6410580-B1 | ANTIINFLAMMATORY AGENTS, RHEUMATIC DISEASES | NOVARTIS AG (CH) | 2002-06-25 | — | — | US | disclosed |
| US-6277987-B1 | FOR INHIBITING MATRIX-DEGRADING METALLOPROTEINASES IN MAMMALS | NOVARTIS AG (CH) | 2001-08-21 | — | — | US | disclosed |