Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPSAB1 | Q15661 | 3/20 | 0.55 |
| ▸ | TPSD1 | Q9BZJ3 | 3/20 | 0.55 |
| ▸ | TPSG1 | Q9NRR2 | 3/20 | 0.55 |
| ▸ | CA9 | Q16790 | 8/20 | 0.50 |
| ▸ | CA12 | O43570 | 7/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 4/20 | 0.47 |
| ▸ | ELANE | P08246 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP3 | P08254 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5033315 | 0.83 | CA9 (0.54) | TPSAB1TPSD1TPSG1CA9CA12 | |
| SCHEMBL5033293 | 0.82 | MMP2 (0.46) | HDAC1HDAC2MMP2MMP3MMP9 | |
| SCHEMBL5036997 | 0.80 | MMP13 (0.44) | TPSAB1TPSD1TPSG1CA9CA12 | |
| SCHEMBL8282041 | 0.78 | TPSAB1 (0.54) | TPSAB1TPSD1TPSG1CA9CA12 | |
| SCHEMBL13622671 | 0.78 | TPSAB1 (0.54) | TPSAB1TPSD1TPSG1CA9CA12 | |
| SCHEMBL14969045 | 0.73 | GAA (0.43) | GAA | |
| SCHEMBL31649378 | 0.73 | ALDH1A1 (0.51) | HDAC1MMP2MMP3MMP9MMP13 | |
| SCHEMBL2640680 | 0.73 | ALDH1A1 (0.51) | HDAC1MMP2MMP3MMP9MMP13 | |
| SCHEMBL2640679 | 0.73 | ALDH1A1 (0.51) | HDAC1MMP2MMP3MMP9MMP13 | |
| SCHEMBL7393272 | 0.73 | HTR1A (0.52) | TPSAB1TPSD1TPSG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1918278-A1 | Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases | Novartis AG (CH) | 2008-05-07 | — | — | EP | disclosed |
| US-6410580-B1 | ANTIINFLAMMATORY AGENTS, RHEUMATIC DISEASES | NOVARTIS AG (CH) | 2002-06-25 | — | — | US | disclosed |
| US-6277987-B1 | FOR INHIBITING MATRIX-DEGRADING METALLOPROTEINASES IN MAMMALS | NOVARTIS AG (CH) | 2001-08-21 | — | — | US | disclosed |