Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 5/20 | 0.73 |
| ▸ | PHF8 | Q9UPP1 | 5/20 | 0.73 |
| ▸ | KDM2A | Q9Y2K7 | 5/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.73 |
| ▸ | KDM5C | P41229 | 3/20 | 0.73 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.73 |
| ▸ | KDM6B | O15054 | 1/20 | 0.73 |
| ▸ | ECE1 | P42892 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.41 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.41 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL240068 | 0.85 | — | — | |
| Trifluoroacetic Acid SCHEMBL27603407 | 0.83 | FOLH1 (0.48) | FOLH1PHF8KDM2AKDM4EKDM5C | |
| Succinic Acid SCHEMBL29896406 | 0.83 | LMNA (0.60) | FOLH1PHF8KDM2AKDM4EKDM5C | |
| Succinic Acid SCHEMBL29896408 | 0.83 | LMNA (0.60) | FOLH1PHF8KDM2AKDM4EKDM5C | |
| Octanedioate SCHEMBL4585405 | 0.76 | FOLH1 (0.80) | FOLH1PHF8KDM2AKDM4EKDM5C | |
| Succinic Acid SCHEMBL28172524 | 0.74 | PHF8 (0.76) | FOLH1PHF8KDM2AKDM4EKDM5C | |
| Trifluoroacetic Acid SCHEMBL11688514 | 0.74 | CA2 (0.40) | FOLH1PHF8KDM2AKDM4EKDM5C | |
| Succinodihydroxamic Acid SCHEMBL940650 | 0.74 | FOLH1 (0.75) | FOLH1PHF8KDM2AKDM4EKDM5C | |
| Glutarate SCHEMBL4768243 | 0.72 | SLC22A6 (0.65) | FOLH1EGLN1HDAC3HDAC1HDAC2 | |
| Trifluoroacetic Acid SCHEMBL28035892 | 0.72 | LDHA (0.60) | KDM4EEGLN1LMNAALKBH5SUCNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8778626-B2 | Clickable cross-linker | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2014-07-15 | — | — | US | disclosed |
| US-20120028285-A1 | Clickable cross-linker | NATIONAL SCIENCE FOUNDATION | 2012-02-02 | — | — | US | disclosed |
| WO-2012006603-A2 | CLICKABLE CROSS-LINKER | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2012-01-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028285-A1 | Clickable cross-linker | MTCL3, SPPL2B, VIP | FOLH1 334/4885PHF8 4038/4885KDM2A 3990/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.