Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 3/20 | 0.47 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | BTN3A1 | O00481 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11235663 | 0.85 | FDPS (0.43) | FDPSNAPRTKDM4ETBXAS1CYP3A4 | |
| SCHEMBL14331820 | 0.82 | CYP3A4 (0.51) | CYP3A4CYP1A2ALDH1A1 | |
| SCHEMBL7345369 | 0.81 | MMP8 (0.52) | FDPSNAPRTKDM4ETBXAS1CYP3A4 | |
| SCHEMBL9280186 | 0.79 | NAPRT (0.54) | NAPRTKDM4ETBXAS1CYP3A4KMT2A | |
| SCHEMBL11221097 | 0.77 | TBXAS1 (0.49) | NAPRTKDM4ETBXAS1CYP3A4LMNA | |
| SCHEMBL5041959 | 0.77 | KDM4E (0.43) | FDPSNAPRTKDM4ETBXAS1KMT2A | |
| SCHEMBL6885074 | 0.76 | KDM4E (0.62) | FDPSNAPRTKDM4ETBXAS1CYP3A4 | |
| SCHEMBL3949678 | 0.75 | MMP8 (0.54) | FDPSNAPRTKDM4ETBXAS1CYP3A4 | |
| SCHEMBL2429056 | 0.74 | MMP8 (0.49) | FDPSNAPRTKDM4ETBXAS1CYP3A4 | |
| SCHEMBL11594620 | 0.74 | CYP19A1 (0.51) | TBXAS1CYP3A4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1805136-A1 | SUBSTITUTED PHENYLALKANOIC ACIDS | The Institutes for Pharmaceutical Discovery, LLC (US) | 2007-07-11 | — | — | EP | claimed |
| WO-2006050097-A1 | SUBSTITUTED PHENYLALKANOIC ACIDS | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) | 2006-05-11 | — | — | WO | claimed |
| US-20060100251-A1 | Substituted phenylalkanoic acids | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC | 2006-05-11 | — | — | US | claimed |
| EP-1633354-B1 | N-(((((1,3-THIAZOL-2-YL)AMINO)CARBONYL)PHENYL)SULFONYL)PHENYLALANINE DERIVATIVES AND RELATED COMPOUNDS FOR THE TREATMENT OF DIABETES | INST FOR PHARM DISCOVERY INC (US) | 2008-01-23 | — | — | EP | disclosed |
| EP-1633354-B1 | N-(((((1,3-THIAZOL-2-YL)AMINO)CARBONYL)PHENYL)SULFONYL)PHENYLALANINE DERIVATIVES AND RELATED COMPOUNDS FOR THE TREATMENT OF DIABETES | INST FOR PHARM DISCOVERY INC (US) | 2008-01-23 | — | — | EP | disclosed |
| EP-1805136-A1 | SUBSTITUTED PHENYLALKANOIC ACIDS | The Institutes for Pharmaceutical Discovery, LLC (US) | 2007-07-11 | — | — | EP | disclosed |
| WO-2006050097-A1 | SUBSTITUTED PHENYLALKANOIC ACIDS | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) | 2006-05-11 | — | — | WO | disclosed |
| US-20060100251-A1 | Substituted phenylalkanoic acids | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC | 2006-05-11 | — | — | US | disclosed |
| EP-1633354-A2 | N-(((((1,3-THIAZOL-2-YL)AMINO)CARBONYL)PHENYL)SULFONYL)PHENYLALANINE DERIVATIVES AND RELATED COMPOUNDS FOR THE TREATMENT OF DIABETES | The Institutes for Pharmaceutical Discovery, LLC (US) | 2006-03-15 | — | — | EP | disclosed |
| US-20040248937-A1 | Substituted phenylalkanoic acids for the treatment of diabetes | THE INSTITUTE FOR PHARMACEUTICAL DISCOVERY LLC | 2004-12-09 | — | — | US | disclosed |
| WO-2004092146-A2 | N- (((((1,3-THIAZOL-2-YL) AMINO) CARBONYL) PHENYL) SULFONYL) PHENYLALANINE DERIVATIVES AND RELATED COMPOUNDS FOR THE TREATMENT OF DIABETES | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) | 2004-10-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040248937-A1 | Substituted phenylalkanoic acids for the treatment of diabetes | PTP4A1, PTPRJ, PPM1B | FDPS 698/4885NAPRT 1601/4885KDM4E 1445/4885 |
| US-20060100251-A1 | Substituted phenylalkanoic acids | PTPRJ, PTP4A1, PTPN1 | FDPS 792/4885NAPRT 1545/4885KDM4E 1607/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.