Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR3 | Q99500 | 1/20 | 0.45 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | XDH | P47989 | 2/20 | 0.41 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.41 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.41 |
| ▸ | DHODH | Q02127 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.37 |
| ▸ | GCK | P35557 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4422191 | 0.83 | APEX1 (0.44) | S1PR3APEX1SLC6A9MAPK1GCK | |
| SCHEMBL2828683 | 0.83 | LMNA (0.51) | S1PR3XDHSLC22A12SLC6A9DHODH | |
| SCHEMBL5043956 | 0.82 | SLC6A9 (0.45) | S1PR3APEX1SLC6A9KCNH2SYK | |
| SCHEMBL4420113 | 0.80 | S1PR3 (0.47) | S1PR3XDHSLC22A12SLC6A9DHODH | |
| SCHEMBL5037977 | 0.75 | APEX1 (0.42) | APEX1SLC6A9 | |
| SCHEMBL5041907 | 0.75 | PDE4A (0.42) | APEX1SLC6A9SYK | |
| SCHEMBL4420378 | 0.74 | SLC6A9 (0.73) | SLC6A9KCNH2 | |
| SCHEMBL5042083 | 0.74 | SLC6A9 (0.73) | SLC6A9KCNH2 | |
| SCHEMBL4282168 | 0.74 | FOS (0.50) | XDHSLC22A12DHODHTP53 | |
| SCHEMBL4277471 | 0.74 | ABCB1 (0.52) | XDHSLC22A12DHODHSYKTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1656361-B1 | PIPERAZINE WITH OR-SUBSTITUTED PHENYL GROUP AND THEIR USE AS GLYT1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |