Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 3/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5038984 | 0.79 | GLA (0.44) | ALDH1A1ALKBH1TSHRKMT2ALMNA | |
| SCHEMBL16673032 | 0.78 | ALDH1A1 (0.48) | SLC6A4SLC6A3ALDH1A1TSHRKMT2A | |
| SCHEMBL16672583 | 0.77 | ALDH1A1 (0.49) | SLC6A4SLC6A3SLC6A2ALDH1A1TSHR | |
| SCHEMBL5043805 | 0.75 | SLC6A2 (0.45) | SLC6A4SLC6A3SLC6A2KMT2AKCNH2 | |
| SCHEMBL362624 | 0.74 | TDP1 (0.56) | SLC6A4SLC6A3SLC6A2TDP1KMT2A | |
| SCHEMBL3408278 | 0.73 | LMNA (0.46) | SLC6A4SLC6A3SLC6A2ALDH1A1TSHR | |
| SCHEMBL27389987 | 0.73 | LMNA (0.46) | SLC6A4SLC6A3SLC6A2ALDH1A1TSHR | |
| SCHEMBL16672576 | 0.73 | ESR1 (0.44) | ALDH1A1ALKBH1KMT2AGAALMNA | |
| SCHEMBL8358798 | 0.72 | AOC3 (0.48) | SLC6A4SLC6A3SLC6A2TDP1KMT2A | |
| SCHEMBL7681247 | 0.72 | LTB4R (0.51) | SLC6A4SLC6A3SLC6A2ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1677745-A4 | NITRONE COMPOUNDS PRODRUGS AND PHARMACEUTICAL COMPOSITIONS OF THE SAME TO TREAT HUMAN DISORDERS | RENOVIS INC (US) | 2008-10-22 | — | — | EP | disclosed |
| EP-1677745-A2 | NITRONE COMPOUNDS PRODRUGS AND PHARMACEUTICAL COMPOSITIONS OF THE SAME TO TREAT HUMAN DISORDERS | Renovis, Inc. (US) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005037208-A2 | NITRONE COMPOUNDS PRODRUGS AND PHARMACEUTICAL COMPOSITIONS OF THE SAME TO TREAT HUMAN DISORDERS | RENOVIS, INC. (US) | 2005-04-28 | — | — | WO | disclosed |