Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.47 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.45 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.44 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | ERN1 | O75460 | 2/20 | 0.42 |
| ▸ | CFD | P00746 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5047208 | 0.88 | AKR1C3 (0.47) | EPHX2NR1H4AKR1C3TRPV1ALDH1A1 | |
| SCHEMBL5047990 | 0.86 | EPHX2 (0.51) | EPHX2NR1H4AKR1C4AKR1C3AKR1C2 | |
| SCHEMBL6022309 | 0.83 | EPHX2 (0.46) | EPHX2NR1H4SCN2ASCN10ATRPV1 | |
| SCHEMBL1854934 | 0.82 | EPHX2 (0.49) | EPHX2NR1H4AKR1C4AKR1C3AKR1C2 | |
| SCHEMBL5046973 | 0.78 | UTS2R (0.47) | EPHX2NR1H4AKR1C4AKR1C3AKR1C2 | |
| SCHEMBL5045075 | 0.77 | P2RX7 (0.46) | EPHX2NR1H4SCN2ASCN10A | |
| SCHEMBL5046329 | 0.76 | ALDH1A1 (0.48) | EPHX2AKR1C3ERN1ALDH1A1POLB | |
| SCHEMBL5049330 | 0.76 | ALDH1A1 (0.48) | EPHX2AKR1C3ERN1ALDH1A1POLB | |
| SCHEMBL1855976 | 0.75 | EPHX2 (0.55) | EPHX2NR1H4TRPV1ERN1CFD | |
| SCHEMBL11743722 | 0.74 | KCNH2 (0.56) | TRPV1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | claimed |