Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.45 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.45 |
| ▸ | KDM1A | O60341 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | PLK1 | P53350 | 1/20 | 0.42 |
| ▸ | LSS | P48449 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 2/20 | 0.42 |
| ▸ | PPARD | Q03181 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | GRK2 | P25098 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5043909 | 0.88 | EPHX2 (0.47) | AKR1C3EPHX2NR1H4TRPV1ALDH1A1 | |
| SCHEMBL5049330 | 0.88 | ALDH1A1 (0.48) | AKR1C3EPHX2HDAC1ALDH1A1POLB | |
| SCHEMBL5046329 | 0.88 | ALDH1A1 (0.48) | AKR1C3EPHX2HDAC1ALDH1A1POLB | |
| SCHEMBL1851264 | 0.83 | LSS (0.48) | AKR1C3EPHX2NR1H4KDM1AHDAC1 | |
| SCHEMBL5039647 | 0.78 | TACR1 (0.54) | AKR1C3EPHX2NR1H4PPARG | |
| SCHEMBL5047990 | 0.74 | EPHX2 (0.51) | AKR1C3EPHX2NR1H4HDAC1TRPV1 | |
| SCHEMBL4321965 | 0.74 | LSS (0.57) | AKR1C3EPHX2KDM1AHDAC1TRPV1 | |
| SCHEMBL5048905 | 0.74 | AKR1C4 (0.44) | AKR1C3EPHX2NR1H4HDAC1TRPV1 | |
| SCHEMBL1855976 | 0.73 | EPHX2 (0.55) | EPHX2NR1H4HDAC1TRPV1POLB | |
| SCHEMBL1858311 | 0.73 | MLYCD (0.50) | TRPV1PLK1LSSMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | claimed |