Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLYCD | O95822 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 7/20 | 0.43 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.42 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.42 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5044228 | 0.90 | NAMPT (0.46) | MLYCDHDAC3HDAC1HDAC2TRPV1 | |
| SCHEMBL5048870 | 0.88 | MLYCD (0.52) | MLYCDHDAC3HDAC1PDK1PDK2 | |
| SCHEMBL6023237 | 0.87 | EPHX2 (0.49) | HDAC3HDAC1HDAC2TRPV1NAMPT | |
| SCHEMBL5045572 | 0.82 | ALDH1A1 (0.49) | MLYCDHDAC3HDAC1HDAC2PDK1 | |
| SCHEMBL5044219 | 0.81 | MLYCD (0.48) | MLYCDHDAC3HDAC1HDAC2TRPV1 | |
| SCHEMBL6022083 | 0.81 | TRPV1 (0.48) | MLYCDHDAC3HDAC1HDAC2TRPV1 | |
| SCHEMBL24119885 | 0.79 | MLYCD (0.68) | MLYCDHDAC3HDAC1HDAC2TRPV1 | |
| SCHEMBL1851709 | 0.77 | GCGR (0.48) | MLYCDHDAC3HDAC1HDAC2TRPV1 | |
| SCHEMBL5044895 | 0.76 | EPHX2 (0.48) | HDAC3HDAC1HDAC2TRPV1EPHX2 | |
| SCHEMBL5044232 | 0.76 | MAPK14 (0.49) | MLYCDHDAC3HDAC1TRPV1NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | claimed |