Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 4/20 | 0.49 |
| ▸ | PPARA | Q07869 | 4/20 | 0.49 |
| ▸ | PPARG | P37231 | 3/20 | 0.49 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PPARD | Q03181 | 2/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5044895 | 0.90 | EPHX2 (0.48) | EPHX2PPARAPPARGNR1H4ALDH1A1 | |
| SCHEMBL5048687 | 0.87 | EPHX2 (0.48) | EPHX2PPARAPPARGNR1H4ALDH1A1 | |
| SCHEMBL5044218 | 0.87 | MLYCD (0.47) | EPHX2PPARAPPARGALDH1A1HPGD | |
| SCHEMBL5044609 | 0.86 | EPHX2 (0.52) | EPHX2PPARAPPARGNR1H4ALDH1A1 | |
| SCHEMBL5044633 | 0.85 | PPARG (0.45) | EPHX2PPARAPPARGNR1H4ALDH1A1 | |
| SCHEMBL5044608 | 0.84 | EPHX2 (0.49) | EPHX2PPARAPPARGNR1H4ALDH1A1 | |
| SCHEMBL5047681 | 0.81 | DDR1 (0.43) | EPHX2PPARAPPARGNR1H4ALDH1A1 | |
| SCHEMBL6023307 | 0.81 | HTR2C (0.44) | EPHX2PPARAPPARGNR1H4ALDH1A1 | |
| SCHEMBL1853096 | 0.81 | ALDH1A1 (0.46) | EPHX2PPARAPPARGNR1H4ALDH1A1 | |
| SCHEMBL5044898 | 0.79 | EPHX2 (0.51) | EPHX2PPARAPPARGNR1H4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-A1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | Applied Research Systems ARS Holding N.V. (AN) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005082347-A1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | APLLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2005-09-09 | — | — | WO | disclosed |