Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | NAAA | Q02083 | 2/20 | 0.49 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5140051 | 0.84 | SMN1; SMN2 (0.49) | SMN1; SMN2CA2NAAAGAAL3MBTL1 | |
| SCHEMBL1856259 | 0.83 | SMN1; SMN2 (0.52) | SMN1; SMN2CA2NAAANAMPTGAA | |
| SCHEMBL1856260 | 0.83 | ALDH1A1 (0.53) | SMN1; SMN2CA2NAAANAMPTGAA | |
| SCHEMBL5049250 | 0.82 | SMN1; SMN2 (0.48) | SMN1; SMN2CA2NAAANAMPTGAA | |
| SCHEMBL5046272 | 0.79 | NAAA (0.57) | SMN1; SMN2NAAAL3MBTL1HDAC3HDAC1 | |
| SCHEMBL1854307 | 0.78 | NAAA (0.48) | SMN1; SMN2CA2NAAANAMPTGAA | |
| SCHEMBL27291920 | 0.77 | CA2 (0.74) | SMN1; SMN2CA2NAAANAMPTALDH1A1 | |
| SCHEMBL5048825 | 0.76 | NAMPT (0.50) | SMN1; SMN2NAAANAMPTGAAL3MBTL1 | |
| SCHEMBL6359372 | 0.76 | SMN1; SMN2 (0.72) | SMN1; SMN2CA2NAAAGAAALDH1A1 | |
| SCHEMBL6535127 | 0.75 | SMN1; SMN2 (0.87) | SMN1; SMN2CA2NAAAGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | claimed |