Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | NAAA | Q02083 | 2/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.43 |
| ▸ | STS | P08842 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | SNCA | P37840 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6359399 | 0.80 | SMN1; SMN2 (0.72) | NAMPTSMN1; SMN2NAAAHDAC3GAA | |
| SCHEMBL5540070 | 0.78 | NAMPT (0.73) | NAMPTSMN1; SMN2NAAAHDAC3GAA | |
| SCHEMBL1854024 | 0.78 | NAAA (0.49) | NAMPTSMN1; SMN2NAAAHDAC3GAA | |
| SCHEMBL5044038 | 0.78 | L3MBTL1 (0.52) | NAMPTSMN1; SMN2NAAAHDAC3MAPT | |
| SCHEMBL5044291 | 0.76 | SMN1; SMN2 (0.50) | NAMPTSMN1; SMN2NAAAHDAC3GAA | |
| SCHEMBL5140051 | 0.76 | SMN1; SMN2 (0.49) | SMN1; SMN2NAAAHDAC3GAAMAPT | |
| SCHEMBL12988864 | 0.75 | L3MBTL1 (0.63) | NAMPTSMN1; SMN2HDAC3GAAADORA2A | |
| SCHEMBL6535127 | 0.74 | SMN1; SMN2 (0.87) | SMN1; SMN2NAAAGAAMAPTL3MBTL1 | |
| SCHEMBL131829 | 0.74 | SMN1; SMN2 (0.87) | SMN1; SMN2NAAAGAAMAPTL3MBTL1 | |
| SCHEMBL5039801 | 0.74 | SIGMAR1 (0.53) | NAMPTSMN1; SMN2NAAAHDAC3GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | claimed |