Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 1/20 | 0.49 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 10/20 | 0.38 |
| ▸ | TOP2A | P11388 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.36 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.34 |
| ▸ | ROS1 | P08922 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.34 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9386045 | 0.82 | AHR (0.47) | AHRMDM2JAK2TOP2ALRRK2 | |
| SCHEMBL25777055 | 0.81 | TOP2A (0.48) | AHRMDM2JAK2TOP2AMAPT | |
| SCHEMBL421641 | 0.73 | AHR (0.54) | AHRMDM2JAK2LRRK2MAPT | |
| SCHEMBL29969658 | 0.73 | AHR (0.60) | AHRMDM2JAK2TOP2AKIT | |
| SCHEMBL20990490 | 0.66 | AHR (1.00) | AHRMDM2JAK2TOP2AKIT | |
| SCHEMBL11804205 | 0.65 | CCR1 (0.54) | — | |
| SCHEMBL17402501 | 0.64 | ALDH1A1 (0.54) | AHRLRRK2TP53MAPTACVR1 | |
| SCHEMBL30462618 | 0.64 | LRRK2 (0.59) | LRRK2CSNK1G1CHEK1MAPTROS1 | |
| SCHEMBL181764 | 0.64 | LRRK2 (0.59) | LRRK2CSNK1G1CHEK1MAPTROS1 | |
| SCHEMBL17816635 | 0.64 | LRRK2 (0.59) | LRRK2CSNK1G1CHEK1MAPTROS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1994003433-A1 | BIOLOGICAL APPLICATIONS OF ALKALOIDS DERIVED FROM THE TUNICATE EUDISTOMA sp. | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 1994-02-17 | — | — | WO | claimed |
| EP-1663239-A4 | POTASSIUM CHANNEL MEDIATED DELIVERY OF AGENTS THROUGH THE BLOOD-BRAIN BARRIER | CEDARS SINAI MEDICAL CENTER (US) | 2008-07-23 | — | — | EP | disclosed |
| EP-1663239-A2 | POTASSIUM CHANNEL MEDIATED DELIVERY OF AGENTS THROUGH THE BLOOD-BRAIN BARRIER | CEDARS-SINAI MEDICAL CENTER (US) | 2006-06-07 | — | — | EP | disclosed |
| US-20050089473-A1 | Potassium channel mediated delivery of agents through the blood-brain barrier | CEDARS-SINAI MEDICAL CENTER | 2005-04-28 | — | — | US | disclosed |
| WO-2005025511-A2 | POTASSIUM CHANNEL MEDIATED DELIVERY OF AGENTS THROUGH THE BLOOD-BRAIN BARRIER | CEDARS-SINAI MEDICAL CENTER (US) | 2005-03-24 | — | — | WO | disclosed |
| US-5432172-A | Biological applications of alkaloids derived from the tunicate Eudistoma sp. | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 1995-07-11 | — | — | US | disclosed |
| US-5432172-A | Biological applications of alkaloids derived from the tunicate Eudistoma sp. | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 1995-07-11 | — | — | US | disclosed |
| WO-1994003433-A1 | BIOLOGICAL APPLICATIONS OF ALKALOIDS DERIVED FROM THE TUNICATE EUDISTOMA sp. | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 1994-02-17 | — | — | WO | disclosed |
| WO-1994003433-A1 | BIOLOGICAL APPLICATIONS OF ALKALOIDS DERIVED FROM THE TUNICATE EUDISTOMA sp. | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 1994-02-17 | — | — | WO | disclosed |
| US-5278168-A | Biological applications of alkaloids derived from the tunicate Eudistoma sp. | THE RESEARCH FOUNDATION OF STATE UNIVERISTY OF NEW YORK (US) | 1994-01-11 | — | — | US | disclosed |
| US-5278168-A | Biological applications of alkaloids derived from the tunicate Eudistoma sp. | THE RESEARCH FOUNDATION OF STATE UNIVERISTY OF NEW YORK (US) | 1994-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050089473-A1 | Potassium channel mediated delivery of agents through the blood-brain barrier | KCNN2, KCNN1, KCNN3 | AHR 3307/4885MDM2 3883/4885JAK2 854/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.