Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C4 | P17516 | 6/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 6/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 5/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | KLKB1 | P03952 | 3/20 | 0.39 |
| ▸ | RARB | P10826 | 2/20 | 0.39 |
| ▸ | RARA | P10276 | 1/20 | 0.39 |
| ▸ | RARG | P13631 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4325004 | 0.82 | AKR1C4 (0.40) | AKR1C4AKR1C3AKR1C2TRPV1KLKB1 | |
| SCHEMBL1856241 | 0.76 | TRPV1 (0.42) | TRPV1KLKB1LMNAHPGDPOLB | |
| SCHEMBL5043909 | 0.74 | EPHX2 (0.47) | AKR1C4AKR1C3AKR1C2TRPV1HPGD | |
| SCHEMBL5047208 | 0.74 | AKR1C3 (0.47) | AKR1C3TRPV1POLBEPHX2NR1H4 | |
| SCHEMBL6022152 | 0.72 | DRD2 (0.43) | LMNAHPGDL3MBTL1 | |
| SCHEMBL1854176 | 0.70 | NAAA (0.40) | HDAC1HDAC2 | |
| SCHEMBL6022102 | 0.69 | LSS (0.47) | TRPV1EPHX2HDAC1HDAC8 | |
| SCHEMBL5048336 | 0.69 | NAAA (0.41) | LMNAL3MBTL1HDAC1HDAC2 | |
| SCHEMBL1861363 | 0.69 | TRPV1 (0.40) | TRPV1LMNAHPGDL3MBTL1HDAC3 | |
| SCHEMBL4197091 | 0.68 | TRPV1 (0.66) | TRPV1RARBRARAEPHX2NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | claimed |