Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | NAAA | Q02083 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 5/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5049475 | 0.89 | NPC1 (0.56) | SMN1; SMN2NAAANPC1RAB9AALDH1A1 | |
| SCHEMBL1857104 | 0.87 | ALDH1A1 (0.53) | SMN1; SMN2NAAANPC1RAB9AALDH1A1 | |
| SCHEMBL5041082 | 0.85 | NAAA (0.60) | SMN1; SMN2NAAAKMT2ALMNATMEM97 | |
| SCHEMBL5039921 | 0.84 | SMN1; SMN2 (0.56) | SMN1; SMN2NAAANPC1RAB9ALMNA | |
| SCHEMBL5044104 | 0.84 | SMN1; SMN2 (0.52) | SMN1; SMN2NAAAMAPTGAALMNA | |
| SCHEMBL28752185 | 0.84 | SNCA (0.55) | SMN1; SMN2NAAANPC1RAB9AALDH1A1 | |
| SCHEMBL5040331 | 0.84 | SMN1; SMN2 (0.54) | SMN1; SMN2NAAATMEM97SIGMAR1L3MBTL1 | |
| SCHEMBL5044578 | 0.82 | SMN1; SMN2 (0.48) | SMN1; SMN2NAAANPC1RAB9AKMT2A | |
| SCHEMBL5044747 | 0.81 | HDAC2 (0.52) | SMN1; SMN2NAAANPC1RAB9AGAA | |
| SCHEMBL5039808 | 0.81 | GAA (0.56) | SMN1; SMN2NAAANPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | claimed |