Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | NAAA | Q02083 | 2/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27601019 | 0.88 | HDAC8 (0.64) | SNCASMN1; SMN2NAAAHDAC8HDAC6 | |
| SCHEMBL1855176 | 0.85 | NAAA (0.68) | SMN1; SMN2NAAAHDAC8NPC1RAB9A | |
| SCHEMBL27601110 | 0.84 | SMN1; SMN2 (0.54) | SNCASMN1; SMN2NAAAHDAC8HDAC6 | |
| SCHEMBL5047548 | 0.84 | SMN1; SMN2 (0.51) | SMN1; SMN2NAAAHDAC8HDAC6NPC1 | |
| SCHEMBL1857104 | 0.83 | ALDH1A1 (0.53) | SMN1; SMN2NAAAHDAC6NPC1ALDH1A1 | |
| SCHEMBL27601089 | 0.83 | NAAA (0.62) | SMN1; SMN2NAAAHDAC8ALDH1A1ROCK2 | |
| SCHEMBL27619583 | 0.83 | SMN1; SMN2 (0.58) | SMN1; SMN2NAAAHDAC8ROCK2L3MBTL1 | |
| SCHEMBL28752186 | 0.82 | SMN1; SMN2 (0.49) | SMN1; SMN2NAAAHDAC8NPC1RAB9A | |
| SCHEMBL28752189 | 0.82 | SMN1; SMN2 (0.57) | SMN1; SMN2NAAAHDAC8ROCK2L3MBTL1 | |
| SCHEMBL5044022 | 0.80 | MRGPRX4 (0.56) | SMN1; SMN2NAAAALDH1A1MLYCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100410236-C | Substituted methylene amide derivatives as protein tyrosine phosphatase modulators | APPLIED RESEARCH SYSTEMS (CH) | 2008-08-13 | — | — | CN | disclosed |
| CN-1633410-A | Substituted methylene amide derivatives as protein tyrosine phosphatase modulators | APPLIED RESEARCH SYSTEMS (AN) | 2005-06-29 | — | — | CN | disclosed |