Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 8/20 | 0.36 |
| ▸ | TNKS | O95271 | 2/20 | 0.34 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.33 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | SSTR5 | P35346 | 2/20 | 0.31 |
| ▸ | F10 | P00742 | 1/20 | 0.31 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3847249 | 0.82 | HRH4 (0.42) | EGLN1PARP1KCNH2PARP2SLC6A2 | |
| SCHEMBL5047640 | 0.77 | MPO (0.36) | PARP1KCNH2DRD2HTR2AHTR1A | |
| SCHEMBL3846941 | 0.72 | KCNH2 (0.47) | PARP1KCNH2PARP2HTR2AHTR1A | |
| SCHEMBL5044764 | 0.72 | PARP1 (0.32) | PARP1KCNH2PARP2 | |
| SCHEMBL5050024 | 0.70 | MPO (0.35) | PARP1KCNH2PARP2DRD2HTR2A | |
| SCHEMBL4733245 | 0.70 | NPSR1 (0.46) | EGLN1DRD2 | |
| SCHEMBL5050047 | 0.68 | KCNH2 (0.35) | PARP1KCNH2PARP2DRD2HTR2A | |
| SCHEMBL5051229 | 0.65 | MPO (0.34) | PARP1KCNH2DRD2HTR2AHTR1A | |
| SCHEMBL3844281 | 0.65 | PARP1 (0.37) | PARP1PARP2DAODDO | |
| SCHEMBL5044755 | 0.65 | ALDH1A1 (0.39) | DRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893599-A1 | COMPOUNDS FOR THE TREATMENT OF MULTI-DRUG RESISTANT BACTERIAL INFECTIONS | AstraZeneca AB (SE) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006134378-A1 | COMPOUNDS FOR THE TREATMENT OF MULTI-DRUG RESISTANT BACTERIAL INFECTIONS | ASTRAZENECA AB (SE) | 2006-12-21 | — | — | WO | disclosed |