Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | ACACB | O00763 | 1/20 | 0.44 |
| ▸ | NEK2 | P51955 | 1/20 | 0.41 |
| ▸ | ERN1 | O75460 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.37 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3422014 | 0.84 | ALDH1A1 (0.37) | ALDH1A1HPGDSMN1; SMN2ACACBMAPT | |
| SCHEMBL1004649 | 0.82 | ALDH1A1 (0.73) | ALDH1A1HPGDSMN1; SMN2ERN1MAOB | |
| SCHEMBL6320976 | 0.81 | ALDH1A1 (0.55) | ALDH1A1HPGDSMN1; SMN2ACACBERN1 | |
| SCHEMBL123989 | 0.80 | NSD2 (0.42) | ALDH1A1HPGDSMN1; SMN2ACACB | |
| SCHEMBL10933810 | 0.79 | NSD2 (0.55) | ALDH1A1HPGDSMN1; SMN2ACACBPDK2 | |
| SCHEMBL3610292 | 0.79 | HPGD (0.56) | ALDH1A1HPGDSMN1; SMN2HSP90AA1MAPT | |
| SCHEMBL8160105 | 0.78 | HDAC4 (0.45) | ACACBMAOBPDK2 | |
| SCHEMBL13891405 | 0.78 | ALDH1A1 (0.52) | ALDH1A1HPGDSMN1; SMN2ACACBERN1 | |
| SCHEMBL21115241 | 0.77 | NSD2 (0.43) | ALDH1A1ACACBMAOBAOC3 | |
| SCHEMBL15801078 | 0.77 | DRD2 (0.40) | ACACBMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10889546-B2 | Alkynyl pyridine prolyl hydroxylase inhibitor, and preparation method and medical use thereof | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2021-01-12 | — | — | US | disclosed |
| US-20200407319-A1 | ALKYNYL PYRIDINE PROLYL HYDROXYLASE INHIBITOR, AND PREPARATION METHOD AND MEDICAL USE THEREOF | JIANGSU HENGRUI MEDICINE CO., LTD. | 2020-12-31 | — | — | US | disclosed |
| CN-107848976-B | Alkynyl pyridine prolyl hydroxylase inhibitor, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2020-11-17 | — | — | CN | disclosed |
| EP-3360862-B1 | ALKYNYL PYRIDINE PROLYL HYDROXYLASE INHIBITOR, AND PREPARATION METHOD AND MEDICAL USE THEREOF | JIANGSU HENGRUI MEDICINE CO (CN) | 2020-04-22 | — | — | EP | disclosed |
| US-20180305317-A1 | ALKYNYL PYRIDINE PROLYL HYDROXYLASE INHIBITOR, AND PREPARATION METHOD AND MEDICAL USE THEREOF | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2018-10-25 | — | — | US | disclosed |
| US-7459480-B2 | Benzodioxepine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2008-12-02 | — | — | US | disclosed |
| EP-1682528-B1 | BENZO [b][1,4] DIOXEPINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2007-09-12 | — | — | EP | disclosed |
| EP-1682528-A1 | BENZO [b][1,4] DIOXEPINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-07-26 | — | — | EP | disclosed |
| US-20050113374-A1 | Benzodioxepine derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2005-05-26 | — | — | US | disclosed |
| WO-2005044814-A1 | BENZO [b][1,4] DIOXEPINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2005-05-19 | — | — | WO | disclosed |
| EP-0114632-B1 | 5-(4-VINYL- OR 4-ETHYNYLBENZOYL)-1,2-DIHYDRO-3H-PYRROLO-(1,2-A)-PYRROLE-1-CARBOXYLIC ACIDS AND DERIVATIVES THEREOF | SYNTEX (U.S.A.) INC. (US) | 1987-09-16 | — | — | EP | disclosed |
| US-4560699-A | ANTIPYRETICS, ANTICOAGULANTS, VASODILAAORS, MUSCLE RELAXANTS | SYNTEX (U.S.A.) INC. (US) | 1985-12-24 | — | — | US | disclosed |
| EP-0114632-A1 | 5-(4-Vinyl- or 4-ethynylbenzoyl)-1,2-dihydro-3H-pyrrolo-(1,2-A)-pyrrole-1-carboxylic acids and derivatives thereof | SYNTEX (U.S.A.) INC. (US) | 1984-08-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180305317-A1 | ALKYNYL PYRIDINE PROLYL HYDROXYLASE INHIBITOR, AND PREPARATION METHOD AND MEDICAL USE THEREOF | EGLN3, EGLN2, EPOR | ALDH1A1 54/4885HPGD 247/4885SMN1; SMN2 2171/4885 |
| US-10889546-B2 | Alkynyl pyridine prolyl hydroxylase inhibitor, and preparation method and medical use thereof | EGLN3, EGLN2, EPOR | ALDH1A1 54/4885HPGD 247/4885SMN1; SMN2 2171/4885 |
| US-20200407319-A1 | ALKYNYL PYRIDINE PROLYL HYDROXYLASE INHIBITOR, AND PREPARATION METHOD AND MEDICAL USE THEREOF | EGLN3, EGLN2, EPOR | ALDH1A1 54/4885HPGD 247/4885SMN1; SMN2 2171/4885 |
| US-20050113374-A1 | Benzodioxepine derivatives | BBOX1, ACOX1, ACOX3 | ALDH1A1 361/4885HPGD 260/4885SMN1; SMN2 3955/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.