Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 10/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1727131 | 0.79 | APP (0.59) | APP | |
| SCHEMBL913532 | 0.74 | APP (0.58) | KDM4ERAB9ANPC1ALDH1A1PKM | |
| SCHEMBL5048522 | 0.74 | APP (0.58) | KDM4ERAB9ANPC1ALDH1A1PKM | |
| SCHEMBL1727285 | 0.74 | NPC1 (0.49) | KDM4ERAB9ANPC1ALDH1A1PKM | |
| SCHEMBL2904434 | 0.74 | ALDH1A3 (0.54) | KDM4ERAB9ANPC1ALDH1A1PKM | |
| SCHEMBL15940370 | 0.73 | HRH3 (0.43) | KDM4ERAB9ANPC1ALDH1A1PKM | |
| SCHEMBL2904661 | 0.72 | ALDH1A3 (0.60) | KDM4ERAB9ANPC1ALDH1A1PKM | |
| SCHEMBL1726214 | 0.71 | RAB9A (0.56) | KDM4ERAB9ANPC1ALDH1A1PKM | |
| SCHEMBL2435107 | 0.70 | HRH3 (0.43) | KDM4ERAB9ANPC1ALDH1A1PKM | |
| SCHEMBL4154943 | 0.69 | APP (0.42) | KDM4ERAB9ANPC1ALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE44354-E1 | Amyloid plaque aggregation inhibitors and diagnostic imaging agents | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2013-07-09 | — | — | US | disclosed |
| US-RE44338-E1 | Amyloid plaque aggregation inhibitors and diagnostic imaging agents | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2013-07-02 | — | — | US | disclosed |
| US-7425318-B2 | Amyloid plaque aggregation inhibitors and diagnostic imaging agents | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2008-09-16 | — | — | US | disclosed |
| US-20070254889-A1 | Compounds and methods useful for rescuing cells from beta-amyloid toxicity and treatment of Alzheimer's disease | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2007-11-01 | — | — | US | disclosed |
| EP-1381604-B1 | AMYLOID PLAQUE AGGREGATION INHIBITORS AND DIAGNOSTIC IMAGING AGENTS | UNIV PENNSYLVANIA (US) | 2006-12-27 | — | — | EP | disclosed |
| US-20060051293-A1 | Amyloid plaque aggregation inhibitors and diagnostic imaging agents | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2006-03-09 | — | — | US | disclosed |
| US-6946116-B2 | Amyloid plaque aggregation inhibitors and diagnostic imaging agents | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2005-09-20 | — | — | US | disclosed |
| US-20040131545-A1 | Amyloid plaque aggregation inhibitors and diagnostic imaging agents | TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2004-07-08 | — | — | US | disclosed |
| US-6696039-B2 | 2-PHENYL-IMIDAZO(1,2A)PYRIDINE DERIVATIVES | TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2004-02-24 | — | — | US | disclosed |
| US-20030059369-A1 | Amyloid plaque aggregation inhibitors and diagnostic imaging agents | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2003-03-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060051293-A1 | Amyloid plaque aggregation inhibitors and diagnostic imaging agents | APP, APBA1, IAPP | KDM4E 4657/4885RAB9A 2707/4885NPC1 117/4885 |
| US-20030059369-A1 | Amyloid plaque aggregation inhibitors and diagnostic imaging agents | APP, APBA1, IAPP | KDM4E 4657/4885RAB9A 2707/4885NPC1 117/4885 |
| US-20040131545-A1 | Amyloid plaque aggregation inhibitors and diagnostic imaging agents | APP, APBA1, BACE1 | KDM4E 4655/4885RAB9A 2690/4885NPC1 126/4885 |
| US-20070254889-A1 | Compounds and methods useful for rescuing cells from beta-amyloid toxicity and treatment of Alzheimer's disease | APP, BACE1, IAPP | KDM4E 1627/4885RAB9A 327/4885NPC1 37/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.