Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 9/20 | 0.58 |
| ▸ | RAB9A | P51151 | 7/20 | 0.56 |
| ▸ | NPC1 | O15118 | 6/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL913532 | 0.83 | APP (0.58) | APPRAB9ANPC1KDM4EKMT2A | |
| SCHEMBL20019411 | 0.80 | RAB9A (0.59) | APPRAB9ANPC1KDM4EKMT2A | |
| SCHEMBL2900984 | 0.79 | RAB9A (0.58) | APPRAB9ANPC1KDM4EKMT2A | |
| SCHEMBL4154943 | 0.75 | APP (0.42) | APPRAB9ANPC1KDM4ESMN1; SMN2 | |
| SCHEMBL5048495 | 0.74 | KDM4E (0.35) | APPRAB9ANPC1KDM4EKMT2A | |
| SCHEMBL5048521 | 0.74 | APP (1.00) | APPRAB9ANPC1PAX8 | |
| SCHEMBL970456 | 0.73 | ALDH1A3 (0.69) | APPRAB9ANPC1KDM4EKMT2A | |
| SCHEMBL17179184 | 0.72 | SMN1; SMN2 (1.00) | APPRAB9ANPC1KDM4EKMT2A | |
| SCHEMBL5302309 | 0.71 | ALDH1A3 (0.75) | APPRAB9ANPC1KDM4EKMT2A | |
| SCHEMBL4938141 | 0.71 | DYRK1A (0.36) | RAB9ANPC1KDM4EMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE44354-E1 | Amyloid plaque aggregation inhibitors and diagnostic imaging agents | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2013-07-09 | — | — | US | disclosed |
| US-RE44338-E1 | Amyloid plaque aggregation inhibitors and diagnostic imaging agents | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2013-07-02 | — | — | US | disclosed |
| US-7425318-B2 | Amyloid plaque aggregation inhibitors and diagnostic imaging agents | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2008-09-16 | — | — | US | disclosed |
| US-20070254889-A1 | Compounds and methods useful for rescuing cells from beta-amyloid toxicity and treatment of Alzheimer's disease | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2007-11-01 | — | — | US | disclosed |
| EP-1381604-B1 | AMYLOID PLAQUE AGGREGATION INHIBITORS AND DIAGNOSTIC IMAGING AGENTS | UNIV PENNSYLVANIA (US) | 2006-12-27 | — | — | EP | disclosed |
| US-20060051293-A1 | Amyloid plaque aggregation inhibitors and diagnostic imaging agents | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2006-03-09 | — | — | US | disclosed |
| US-6946116-B2 | Amyloid plaque aggregation inhibitors and diagnostic imaging agents | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2005-09-20 | — | — | US | disclosed |
| US-20040131545-A1 | Amyloid plaque aggregation inhibitors and diagnostic imaging agents | TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2004-07-08 | — | — | US | disclosed |
| US-6696039-B2 | 2-PHENYL-IMIDAZO(1,2A)PYRIDINE DERIVATIVES | TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2004-02-24 | — | — | US | disclosed |
| EP-1381604-A2 | AMYLOID PLAQUE AGGREGATION INHIBITORS AND DIAGNOSTIC IMAGING AGENTS | University of Pennsylvania - Centre for Technology (US) | 2004-01-21 | — | — | EP | disclosed |
| US-20030059369-A1 | Amyloid plaque aggregation inhibitors and diagnostic imaging agents | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2003-03-27 | — | — | US | disclosed |
| WO-2002085903-A2 | AMYLOID PLAQUE AGGREGATION INHIBITORS AND DIAGNOSTIC IMAGING AGENTS | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2002-10-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060051293-A1 | Amyloid plaque aggregation inhibitors and diagnostic imaging agents | APP, APBA1, IAPP | APP 1/4885RAB9A 2707/4885NPC1 117/4885 |
| US-20030059369-A1 | Amyloid plaque aggregation inhibitors and diagnostic imaging agents | APP, APBA1, IAPP | APP 1/4885RAB9A 2707/4885NPC1 117/4885 |
| US-20040131545-A1 | Amyloid plaque aggregation inhibitors and diagnostic imaging agents | APP, APBA1, BACE1 | APP 1/4885RAB9A 2690/4885NPC1 126/4885 |
| US-20070254889-A1 | Compounds and methods useful for rescuing cells from beta-amyloid toxicity and treatment of Alzheimer's disease | APP, BACE1, IAPP | APP 1/4885RAB9A 327/4885NPC1 37/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.