Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5048975 | 1.00 | BRD4 (0.34) | BRD4HTTL3MBTL1THRBPARP1 | |
| SCHEMBL14011579 | 0.91 | L3MBTL1 (0.37) | BRD4HTTL3MBTL1THRBPKM | |
| SCHEMBL4044326 | 0.91 | L3MBTL1 (0.37) | BRD4HTTL3MBTL1THRBPKM | |
| SCHEMBL4039778 | 0.91 | L3MBTL1 (0.37) | BRD4HTTL3MBTL1THRBPKM | |
| SCHEMBL5046922 | 0.87 | HPGD (0.36) | BRD4HTTL3MBTL1PKMTP53 | |
| SCHEMBL5046924 | 0.87 | HPGD (0.36) | BRD4HTTL3MBTL1PKMTP53 | |
| SCHEMBL4044752 | 0.87 | L3MBTL1 (0.37) | BRD4L3MBTL1PKMTP53KMT2A | |
| SCHEMBL4046139 | 0.87 | L3MBTL1 (0.37) | BRD4L3MBTL1PKMTP53KMT2A | |
| SCHEMBL4045700 | 0.87 | PKM (0.34) | HTTL3MBTL1PKMTP53KMT2A | |
| SCHEMBL4045702 | 0.87 | PKM (0.34) | HTTL3MBTL1PKMTP53KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7456288-B2 | Heterocyclic compounds and methods of making and using thereof | REDDY US THERAPEUTICS, INC. (US) | 2008-11-25 | — | — | US | disclosed |
| US-20050119269-A1 | Heterocyclic compounds and methods of making and using thereof | DR. REDDY'S LABORATORIES LTD. (IN) | 2005-06-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050119269-A1 | Heterocyclic compounds and methods of making and using thereof | PYGM, MYLK, HMOX1 | BRD4 784/4885HTT 2969/4885L3MBTL1 4807/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.