SCHEMBL5049185

SCHEMBL5049185

CCC(=O)C(C)CNc1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.46
GAA P10253 2/20 0.43
APAF1 O14727 1/20 0.42
MME P08473 1/20 0.41
ACE P12821 1/20 0.41
CES2 O00748 1/20 0.41
CES1 P23141 1/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
ALDH1A1 P00352 2/20 0.41
HTT P42858 1/20 0.41
HDAC3 O15379 2/20 0.41
HDAC4 P56524 2/20 0.41
HDAC1 Q13547 2/20 0.41
HDAC7 Q8WUI4 2/20 0.41
HDAC2 Q92769 2/20 0.41
HDAC10 Q969S8 2/20 0.41
HDAC11 Q96DB2 2/20 0.41
HDAC8 Q9BY41 2/20 0.41
HDAC6 Q9UBN7 2/20 0.41
HDAC9 Q9UKV0 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2507158 0.85 APAF1 (0.58) MAPTGAAAPAF1MMEACE
SCHEMBL16165637 0.85 APAF1 (0.58) MAPTGAAAPAF1MMEACE
SCHEMBL3668257 0.81 GAA (0.50) MAPTGAASMN1; SMN2ALDH1A1MEN1
SCHEMBL27991464 0.81 MAPT (0.42) MAPTGAAAPAF1MMEACE
SCHEMBL23261697 0.80 FADS1 (0.45) MAPTSMN1; SMN2ALDH1A1HTTHDAC4
SCHEMBL13347987 0.77 ALDH1A1 (0.49) MAPTGAASMN1; SMN2ALDH1A1MEN1
SCHEMBL942241 0.76 GAA (0.41) MAPTGAAMMEACESMN1; SMN2
SCHEMBL11019050 0.74 MEN1 (0.56) MAPTGAASMN1; SMN2ALDH1A1HTT
SCHEMBL17109162 0.74 LMNA (0.47) MAPTGAAAPAF1MMEACE
SCHEMBL1674517 0.74 MAPT (0.58) MAPTGAASMN1; SMN2ALDH1A1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1974212-A1 COMPOUNDS USEFUL IN CFTR ASSAYS AND METHODS THEREWITH Vertex Pharmaceuticals Incorporated (US) 2008-10-01 EP disclosed
WO-2007075946-A1 COMPOUNDS USEFUL IN CFTR ASSAYS AND METHODS THEREWITH VERTEX PHARMACEUTICALS INCORPORATED (US) 2007-07-05 WO disclosed
EP-1773816-A2 MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS Vertex Pharmaceuticals Incorporated (US) 2007-04-18 EP disclosed
WO-2006002421-A2 MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS VERTEX PHARMACEUTICALS INCORPORATED (US) 2006-01-05 WO disclosed