SCHEMBL504965

SCHEMBL504965

COc1ccc(F)cc1Br

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.52
MAPT P10636 4/20 0.51
MEN1 O00255 2/20 0.51
KMT2A Q03164 2/20 0.51
PKM P14618 1/20 0.50
TUBB1 Q9H4B7 2/20 0.46
NFE2L2 Q16236 1/20 0.46
HPGD P15428 2/20 0.44
CYP1A2 P05177 1/20 0.44
CYP2D6 P10635 1/20 0.44
CYP2C19 P33261 1/20 0.44
LMNA P02545 1/20 0.43
AMY1A P0DUB6 3/20 0.43
HTR2A P28223 1/20 0.43
NPC1 O15118 1/20 0.42
RAB9A P51151 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
KDM4E B2RXH2 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14482753 1.00 ALDH1A1 (0.52) ALDH1A1MAPTMEN1KMT2APKM
SCHEMBL29849146 1.00 ALDH1A1 (0.52) ALDH1A1MAPTMEN1KMT2APKM
SCHEMBL3823791 0.98 MAPT (0.50) ALDH1A1MAPTMEN1KMT2APKM
SCHEMBL29080411 0.90 L3MBTL1 (0.55) ALDH1A1MAPTMEN1KMT2APKM
SCHEMBL16052098 0.85 PKM (0.46) ALDH1A1MAPTMEN1KMT2APKM
SCHEMBL13667581 0.85 PKM (0.46) ALDH1A1MAPTMEN1KMT2APKM
SCHEMBL29739888 0.85 PKM (0.46) ALDH1A1MAPTMEN1KMT2APKM
SCHEMBL1204321 0.82 AMY1A (0.46) ALDH1A1MAPTMEN1KMT2ANFE2L2
SCHEMBL29712244 0.82 AMY1A (0.46) ALDH1A1MAPTMEN1KMT2ANFE2L2
SCHEMBL27994778 0.81 TDP1 (0.58) ALDH1A1MAPTMEN1KMT2APKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 650 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108623561-B Method for preparing panenonic acid compound 中国海洋大学 2025-04-01 CN claimed
US-20240170736-A1 FLAME RETARDANTS FOR BATTERY ELECTROLYTES ALBEMARLE CORPORATION 2024-05-23 US claimed
EP-4315471-A1 FLAME RETARDANTS FOR BATTERY ELECTROLYTES ALBEMARLE CORPORATION (US) 2024-02-07 EP claimed
CN-117099234-A Flame retardant for battery electrolyte 雅宝公司 2023-11-21 CN claimed
CN-116903449-A Preparation method of 2-bromo-4-fluoroanisole 山东师范大学 2023-10-20 CN claimed
CN-116554378-A Non-metallocene catalyst, preparation method and application 万华化学集团股份有限公司 2023-08-08 CN claimed
WO-2022212637-A1 FLAME RETARDANTS FOR BATTERY ELECTROLYTES ALBEMARLE CORPORATION (US) 2022-10-06 WO claimed
CN-108623581-B Method for preparing paninula compound 中国海洋大学 2021-10-22 CN claimed
CN-108623581-A A method of preparing piperazine Nino peace compound 中国海洋大学 2018-10-09 CN claimed
CN-108623561-A A method of preparing piperazine Nino acid compound 中国海洋大学 2018-10-09 CN claimed
US-7307036-B2 Highly active alpha-olefin polymerization catalyst FORMOSA PLASTICS CORPORATION U.S.A. (US) 2007-12-11 US claimed
US-20060019821-A1 Highly active alpha-olefin polymerization catalyst FORMOSA PLASTICS CORPORATION, U.S.A. 2006-01-26 US claimed
US-RE50634-E1 Diaryl macrocycles as modulators of protein kinases Turning Point Therapeutics, Inc. (US) 2025-10-14 US disclosed
US-12404281-B2 Diaryl macrocycles as modulators of protein kinases Turning Point Therapeutics, Inc. (US) 2025-09-02 US disclosed
US-20250195480-A1 MACROCYCLIC AZOLOPYRIDINE DERIVATIVES AS EED AND PRC2 MODULATORS Fulcrum Therapeutics, Inc. 2025-06-19 US disclosed
CN-108623561-B Method for preparing panenonic acid compound 中国海洋大学 2025-04-01 CN disclosed
US-4448971-A Hypoglycemic 5-phenyl-substituted oxazolidine-2,4-diones PFIZER INC. (US) 1984-05-15 US disclosed
US-4407811-A Hypoglycemic 5-substituted oxazolidine-2,4-diones PFIZER INC. (US) 1983-10-04 US disclosed
US-4399296-A TRIMETHYLSILYL CYANOHYDRIN INTERMEDIATES PFIZER INC. (US) 1983-08-16 US disclosed
US-4367234-A HYPOGLYCEMIC AGENTS PFIZER INC. (US) 1983-01-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12404281-B2 Diaryl macrocycles as modulators of protein kinases MAP3K20, LCK, MAP3K1 ALDH1A1 4630/4885MAPT 1655/4885MEN1 2490/4885
US-20250195480-A1 MACROCYCLIC AZOLOPYRIDINE DERIVATIVES AS EED AND PRC2 MODULATORS EED, EZH2, BMI1 ALDH1A1 1268/4885MAPT 454/4885MEN1 1192/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.