Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERAP2 | Q6P179 | 4/20 | 0.44 |
| ▸ | LNPEP | Q9UIQ6 | 4/20 | 0.44 |
| ▸ | ERAP1 | Q9NZ08 | 3/20 | 0.44 |
| ▸ | MMP9 | P14780 | 2/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | CPB2 | Q96IY4 | 2/20 | 0.42 |
| ▸ | CPB1 | P15086 | 1/20 | 0.42 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.40 |
| ▸ | TLR2 | O60603 | 1/20 | 0.40 |
| ▸ | GNPAT | O15228 | 1/20 | 0.40 |
| ▸ | ECE1 | P42892 | 1/20 | 0.40 |
| ▸ | MME | P08473 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 2/20 | 0.40 |
| ▸ | MMP3 | P08254 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15135507 | 1.00 | ERAP2 (0.44) | ERAP2LNPEPERAP1MMP9MMP2 | |
| SCHEMBL28752252 | 0.92 | LNPEP (0.46) | ERAP2LNPEPERAP1MMP9MMP2 | |
| SCHEMBL1711305 | 0.91 | ERAP2 (0.43) | ERAP2LNPEPERAP1MMP9MMP2 | |
| SCHEMBL1711293 | 0.91 | ERAP2 (0.43) | ERAP2LNPEPERAP1MMP9MMP2 | |
| SCHEMBL5049005 | 0.91 | ERAP2 (0.43) | ERAP2LNPEPERAP1MMP9MMP2 | |
| SCHEMBL5055000 | 0.88 | ERAP2 (0.45) | ERAP2LNPEPERAP1MMP9MMP2 | |
| SCHEMBL5050215 | 0.88 | ERAP2 (0.53) | ERAP2LNPEPERAP1MMP2CPB2 | |
| SCHEMBL5053418 | 0.83 | MMP1 (0.43) | ERAP2LNPEPERAP1MMP9MMP2 | |
| SCHEMBL5050403 | 0.82 | CPB1 (0.54) | CPB2CPB1FOLH1TLR2ECE1 | |
| Benzophenone SCHEMBL28206142 | 0.80 | ERAP2 (0.47) | ERAP2LNPEPERAP1MMP9MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344478-B1 | CC-1065 ANALOGS AND THEIR CONJUGATES | SYNTARGA BV (NL) | 2017-09-27 | — | — | EP | claimed |
| EP-1994000-B1 | WATER-SOLUBLE CC-1065 ANALOGS AND THEIR CONJUGATES | SYNTARGA BV (NL) | 2017-08-23 | — | — | EP | claimed |
| EP-2560645-B1 | CONJUGATES OF CC-1065 ANALOGS AND BIFUNCTIONAL LINKERS | SYNTARGA BV (NL) | 2016-07-13 | — | — | EP | claimed |
| EP-2173739-B1 | SUBSTITUTED CC-1065 ANALOGS AND THEIR CONJUGATES | SYNTARGA BV (NL) | 2013-07-31 | — | — | EP | claimed |
| EP-1370298-B1 | ELONGATED AND MULTIPLE SPACERS IN ACTIVATIBLE PRODRUGS | SYNTARGA BV (NL) | 2008-10-08 | — | — | EP | claimed |