Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4890821 | 0.86 | ALDH1A1 (0.37) | ALDH1A1GAAKDM4EPOLBCTDSP1 | |
| SCHEMBL4893882 | 0.80 | CNR2 (0.42) | ALDH1A1GAAKDM4EHPGDHTT | |
| SCHEMBL4883267 | 0.67 | CYP19A1 (0.47) | ALDH1A1GAAHTTMEN1KMT2A | |
| SCHEMBL11839455 | 0.66 | RXFP1 (0.67) | ALDH1A1KDM4ELMNAMEN1KMT2A | |
| SCHEMBL4890027 | 0.65 | ADORA3 (0.43) | ALDH1A1HPGDHTTLMNAMAPT | |
| SCHEMBL28421136 | 0.64 | AGTR1 (0.62) | AGTR1AGTR2 | |
| SCHEMBL4576546 | 0.64 | PTGS2 (0.49) | ALDH1A1GAAHPGDHTTLMNA | |
| SCHEMBL4789019 | 0.62 | SMN1; SMN2 (0.41) | ALDH1A1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL6168957 | 0.62 | AGTR1 (0.69) | GAANPC1RAB9AAGTR1AGTR2 | |
| SCHEMBL8408236 | 0.62 | KDM4E (0.74) | ALDH1A1GAAKDM4EPOLBCTDSP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968946-A1 | IMIDAZOLES AS GABA-B RECEPTOR MODULATORS | AstraZeneca AB (SE) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007073299-A1 | IMIDAZOLES AS GABA-B RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2007-06-28 | — | — | WO | disclosed |