Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.50 |
| ▸ | CHRM4 known ✓ | P08173 | 2/20 | 0.50 |
| ▸ | CHRM5 known ✓ | P08912 | 2/20 | 0.50 |
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 0.50 |
| ▸ | CHRM3 known ✓ | P20309 | 2/20 | 0.50 |
| ▸ | ACHE known ✓ | P22303 | 10/20 | 0.35 |
| ▸ | CHKA known ✓ | P35790 | 2/20 | 0.34 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.35 |
| ▸ | BCHE | P06276 | 10/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL50687 | 0.80 | HTT (0.55) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL53656 | 0.78 | HTT (0.57) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL20253089 | 0.77 | KCNH2 (0.45) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL20224015 | 0.69 | ACHE (0.67) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL25525834 | 0.68 | TP53 (0.41) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Bromide SCHEMBL50888 | 0.68 | HTT (0.63) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Bromide SCHEMBL1527145 | 0.67 | CHRM2 (1.00) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL17635540 | 0.66 | CHRM2 (0.50) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL53095 | 0.66 | HTT (0.66) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Bromide SCHEMBL21315885 | 0.65 | CHRM2 (0.90) | CHRM2CHRM4CHRM5CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129532-B2 | Amino(oligo)thiophene dyes, preparation thereof, and optical methods of use | THE UNIVERSITY OF CONNECTICUT (US) | 2012-03-06 | — | — | US | disclosed |
| US-20090042227-A1 | AMINO(OLIGO)THIOPHENE DYES, PREPARATION THEREOF, AND OPTICAL METHODS OF USE | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2009-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090042227-A1 | AMINO(OLIGO)THIOPHENE DYES, PREPARATION THEREOF, AND OPTICAL METHODS OF USE | NLN, NME4, OAT | CHRM2 2565/4885CHRM4 780/4885CHRM5 1432/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.