Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.54 |
| ▸ | CHRM4 known ✓ | P08173 | 2/20 | 0.54 |
| ▸ | CHRM5 known ✓ | P08912 | 2/20 | 0.54 |
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 0.54 |
| ▸ | CHRM3 known ✓ | P20309 | 2/20 | 0.54 |
| ▸ | CHKA known ✓ | P35790 | 1/20 | 0.40 |
| ▸ | ACHE known ✓ | P22303 | 6/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | UBE2N | P61088 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.39 |
| ▸ | BCHE | P06276 | 6/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL53656 | 0.98 | HTT (0.57) | HTTCHRM2CHRM4CHRM5CHRM1 | |
| Bromide SCHEMBL50888 | 0.87 | HTT (0.63) | HTTCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL53095 | 0.85 | HTT (0.66) | HTTCHRM2CHRM4CHRM5CHRM1 | |
| Bromide SCHEMBL50527 | 0.80 | CHRM2 (0.50) | HTTCHRM2CHRM4CHRM5CHRM1 | |
| Bromide SCHEMBL50943 | 0.80 | HTT (0.53) | HTTCHKAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL53084 | 0.78 | HTT (0.55) | HTTCHKAMEN1MAPTKMT2A | |
| Bromide SCHEMBL193632 | 0.77 | HTT (0.79) | HTTCHRM2CHRM4CHRM5CHRM1 | |
| Bromide SCHEMBL26090899 | 0.77 | HTT (0.78) | HTTCHKAMEN1MAPTKMT2A | |
| Bromide SCHEMBL30903821 | 0.77 | HTT (0.78) | HTTCHKAMEN1MAPTKMT2A | |
| SCHEMBL18234751 | 0.76 | HTT (0.70) | HTTCHKAMEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8993258-B2 | Fluorinated voltage sensitive dyes, preparation thereof, and optical methods of use | THE UNIVERSITY OF CONNECTICUT (US) | 2015-03-31 | — | — | US | disclosed |
| US-20130330762-A1 | FLUORINATED VOLTAGE SENSITIVE DYES, PREPARATION THEREOF, AND OPTICAL METHODS OF USE | THE UNIVERSITY OF CONNECTICUT (US) | 2013-12-12 | — | — | US | disclosed |
| US-8357350-B2 | Annulus fibrosus detection in intervertebral discs using molecular imaging agents | GENERAL ELECTRIC COMPANY (US) | 2013-01-22 | — | — | US | disclosed |
| US-8129532-B2 | Amino(oligo)thiophene dyes, preparation thereof, and optical methods of use | THE UNIVERSITY OF CONNECTICUT (US) | 2012-03-06 | — | — | US | disclosed |
| US-20100202965-A1 | ANNULUS FIBROSUS DETECTION IN INTERVERTEBRAL DISCS USING MOLECULAR IMAGING AGENTS | GENERAL ELECTRIC COMPANY (US) | 2010-08-12 | — | — | US | disclosed |
| US-20090042227-A1 | AMINO(OLIGO)THIOPHENE DYES, PREPARATION THEREOF, AND OPTICAL METHODS OF USE | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2009-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130330762-A1 | FLUORINATED VOLTAGE SENSITIVE DYES, PREPARATION THEREOF, AND OPTICAL METHODS OF USE | KCNH3, KCNH2, KCNQ2 | CHRM2 153/4885CHRM4 155/4885CHRM5 136/4885 |
| US-20090042227-A1 | AMINO(OLIGO)THIOPHENE DYES, PREPARATION THEREOF, AND OPTICAL METHODS OF USE | NLN, NME4, OAT | CHRM2 2565/4885CHRM4 780/4885CHRM5 1432/4885 |
| US-20100202965-A1 | ANNULUS FIBROSUS DETECTION IN INTERVERTEBRAL DISCS USING MOLECULAR IMAGING AGENTS | BMP1, TMEM14C, NPPA | CHRM2 4752/4885CHRM4 4818/4885CHRM5 4826/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.