Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S100A4 | P26447 | 2/20 | 0.55 |
| ▸ | DAO | P14920 | 2/20 | 0.53 |
| ▸ | CES1 | P23141 | 2/20 | 0.53 |
| ▸ | NSD2 | O96028 | 1/20 | 0.53 |
| ▸ | BCHE | P06276 | 1/20 | 0.53 |
| ▸ | PTPRC | P08575 | 1/20 | 0.50 |
| ▸ | LIG1 | P18858 | 1/20 | 0.49 |
| ▸ | XDH | P47989 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | TDP2 | O95551 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5945174 | 0.78 | KMT2A (0.51) | S100A4PTPRCXDHCA1CA2 | |
| SCHEMBL8616616 | 0.76 | CCNB2 (0.39) | S100A4DAOPTPRCLIG1XDH | |
| SCHEMBL7497126 | 0.74 | KMT2A (0.49) | S100A4PTPRCXDHCA1CA2 | |
| SCHEMBL9016208 | 0.74 | CAPN9 (0.54) | S100A4CES1PTPRCKMT2AMEN1 | |
| SCHEMBL27198984 | 0.74 | ALDH1A1 (0.46) | S100A4PTPRCXDHCA1CA2 | |
| SCHEMBL30776836 | 0.74 | ALDH1A1 (0.46) | S100A4PTPRCXDHCA1CA2 | |
| SCHEMBL4612017 | 0.73 | PARP1 (0.53) | S100A4CES1BCHEPTPRCXDH | |
| SCHEMBL30050991 | 0.73 | SMN1; SMN2 (0.61) | S100A4PTPRCCA1CA2CA7 | |
| SCHEMBL284027 | 0.73 | SMN1; SMN2 (0.61) | S100A4PTPRCCA1CA2CA7 | |
| SCHEMBL505202 | 0.72 | S100A4 (0.49) | S100A4CES1XDHMAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110845388-A | Method for synthesizing 7-nitroindole | 江苏苏利精细化工股份有限公司 | 2020-02-28 | — | — | CN | claimed |
| EP-1432395-B1 | METHOD FOR COLOURING KERATIN FIBRES USING CARBONYL COMPOUNDS TO IMPROVE THE COLOUR STABILITY OF HAIR COLORATION | HENKEL AG & CO KGAA (DE) | 2012-08-08 | — | — | EP | claimed |
| EP-2414328-B1 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | MERCK SERONO SA (CH) | 2021-05-26 | — | — | EP | disclosed |
| EP-2414328-B1 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | MERCK SERONO SA (CH) | 2021-05-26 | — | — | EP | disclosed |
| CN-110845388-A | Method for synthesizing 7-nitroindole | 江苏苏利精细化工股份有限公司 | 2020-02-28 | — | — | CN | disclosed |
| CN-110845388-A | Method for synthesizing 7-nitroindole | 江苏苏利精细化工股份有限公司 | 2020-02-28 | — | — | CN | disclosed |
| CN-110325514-A | Trisubstituted -2- alkyl -1H- benzo [d] imdazole derivatives of 1,4,6- as dihydrooratic acid oxygenase inhibitor | 默克专利有限责任公司 | 2019-10-11 | — | — | CN | disclosed |
| US-9006454-B2 | Dihydroorotate dehydrogenase inhibitors | MERCK SERONO S.A. (CH) | 2015-04-14 | — | — | US | disclosed |
| US-9006454-B2 | Dihydroorotate dehydrogenase inhibitors | MERCK SERONO S.A. (CH) | 2015-04-14 | — | — | US | disclosed |
| US-9006454-B2 | Dihydroorotate dehydrogenase inhibitors | MERCK SERONO S.A. (CH) | 2015-04-14 | — | — | US | disclosed |
| CN-104030987-A | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | MERCK SERONO SA | 2014-09-10 | — | — | CN | disclosed |
| CN-103922948-A | Preparation method of 2-amino-3-nitrobenzoic acid | QINGDAO XUEJIE CHEMICALS CO LTD | 2014-07-16 | — | — | CN | disclosed |
| EP-2414328-A2 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | Merck Serono S.A. (CH) | 2012-02-08 | — | — | EP | disclosed |
| US-20120028959-A1 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | MERCK SERONO S.A. (CH) | 2012-02-02 | — | — | US | disclosed |
| US-20120028959-A1 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | MERCK SERONO S.A. (CH) | 2012-02-02 | — | — | US | disclosed |
| US-20120028959-A1 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | MERCK SERONO S.A. (CH) | 2012-02-02 | — | — | US | disclosed |
| WO-2010115736-A2 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | MERCK SERONO S.A. (CH) | 2010-10-14 | — | — | WO | disclosed |
| WO-2010115736-A2 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | MERCK SERONO S.A. (CH) | 2010-10-14 | — | — | WO | disclosed |
| WO-2001053251-A1 | PROCESS FOR PRODUCING 3-NITRO-2-(MONO-SUBSTITUTED)AMINOBENZOIC ACID ESTER | SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) | 2001-07-26 | — | — | WO | disclosed |
| JP-2001163843-A | METHOD FOR PRODUCING 3-NITRO-2-AMINOBENZOIC ACID | SUMITOMO SEIKA CHEM CO LTD | 2001-06-19 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028959-A1 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | DHODH, FH, DPYD | S100A4 4628/4885DAO 271/4885CES1 846/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.