SCHEMBL505643

SCHEMBL505643

O=C1c2ccccc2C(=O)N1CCCCOc1cc(Br)cc(Br)c1

nearest known ligand 0.66

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 6/20 0.66
MAPT P10636 2/20 0.63
SMN1; SMN2 Q16637 1/20 0.63
HPGD P15428 2/20 0.52
NPSR1 Q6W5P4 2/20 0.52
NPC1 O15118 1/20 0.51
TDP1 Q9NUW8 2/20 0.51
KMT2A Q03164 1/20 0.51
ALDH1A1 P00352 1/20 0.50
LMNA P02545 1/20 0.50
TSHR P16473 1/20 0.50
L3MBTL1 Q9Y468 3/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10679645 0.87 RAB9A (0.58) RAB9AMAPTSMN1; SMN2HPGDNPSR1
SCHEMBL2147069 0.87 RAB9A (0.69) RAB9AMAPTSMN1; SMN2HPGDNPSR1
SCHEMBL10673602 0.85 RAB9A (0.62) RAB9AMAPTSMN1; SMN2HPGDNPSR1
SCHEMBL4235445 0.84 RAB9A (0.86) RAB9AMAPTSMN1; SMN2HPGDNPSR1
SCHEMBL17273630 0.83 RAB9A (0.60) RAB9AMAPTSMN1; SMN2HPGDNPSR1
SCHEMBL1999435 0.83 RAB9A (0.90) RAB9AMAPTSMN1; SMN2HPGDNPSR1
SCHEMBL10675380 0.82 RAB9A (0.59) RAB9AMAPTSMN1; SMN2HPGDNPSR1
SCHEMBL24658769 0.82 RAB9A (0.77) RAB9AMAPTSMN1; SMN2HPGDNPSR1
SCHEMBL11996369 0.81 RAB9A (0.87) RAB9AMAPTSMN1; SMN2HPGDNPSR1
SCHEMBL8554591 0.81 RAB9A (0.87) RAB9AMAPTSMN1; SMN2HPGDNPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 144 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260063640-A1 Reagents for Directed Biomarker Signal Amplification SIRIGEN II LTD (GB) 2026-03-05 US disclosed
US-20250362301-A1 Fluorescent Methods and Materials for Directed Biomarker Signal Amplification SIRIGEN II LTD (GB) 2025-11-27 US disclosed
US-12366578-B2 Fluorescent methods and materials for directed biomarker signal amplification SIRIGEN II LIMITED (GB) 2025-07-22 US disclosed
US-12366577-B2 Fluorescent methods and materials for directed biomarker signal amplification SIRIGEN II LIMITED (GB) 2025-07-22 US disclosed
US-12345713-B2 Reagents for directed biomarker signal amplification SIRIGEN II LIMITED (GB) 2025-07-01 US disclosed
US-12253525-B2 Reagents for directed biomarker signal amplification SIRIGEN II LIMITED (GB) 2025-03-18 US disclosed
US-12241898-B2 Reagents for directed biomarker signal amplification SIRIGEN II LIMITED (GB) 2025-03-04 US disclosed
US-12235274-B2 Reagents for directed biomarker signal amplification SIRIGEN II LIMITED (GB) 2025-02-25 US disclosed
US-12153050-B2 Reagents for directed biomarker signal amplification SIRIGEN II LIMITED (GB) 2024-11-26 US disclosed
US-12111321-B2 Reagents for directed biomarker signal amplification SIRIGEN II LIMITED (GB) 2024-10-08 US disclosed
US-20110256550-A1 Novel reagents for directed biomarker signal amplification SIRIGEN, INC. (US) 2011-10-20 US disclosed
WO-2011091086-A1 NOVEL REAGENTS FOR DIRECTED BIOMARKER SIGNAL AMPLIFICATION SIRIGEN INC. (US) 2011-07-28 WO disclosed
WO-2011091086-A1 NOVEL REAGENTS FOR DIRECTED BIOMARKER SIGNAL AMPLIFICATION SIRIGEN INC. (US) 2011-07-28 WO disclosed
WO-2010151807-A1 SIGNAL AMPLIFIED BIOLOGICAL DETECTION WITH CONJUGATED POLYMERS SIRIGEN, INC. (US) 2010-12-29 WO disclosed
EP-2164988-A2 FLUORESCENT METHODS AND MATERIALS FOR DIRECTED BIOMARKER SIGNAL AMPLIFICATION Sirigen Inc. (US) 2010-03-24 EP disclosed
US-20080293164-A1 Fluorescent Methods and Materials for Directed Biomarker Signal Amplification SIRIGEN INC. 2008-11-27 US disclosed
US-20080293164-A1 Fluorescent Methods and Materials for Directed Biomarker Signal Amplification SIRIGEN INC. 2008-11-27 US disclosed
US-20080293164-A1 Fluorescent Methods and Materials for Directed Biomarker Signal Amplification SIRIGEN INC. 2008-11-27 US disclosed
WO-2008100344-A2 FLUORESCENT METHODS AND MATERIALS FOR DIRECTED BIOMARKER SIGNAL AMPLIFICATION SIRIGEN INC. (US) 2008-08-21 WO disclosed
WO-2008100344-A2 FLUORESCENT METHODS AND MATERIALS FOR DIRECTED BIOMARKER SIGNAL AMPLIFICATION SIRIGEN INC. (US) 2008-08-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12253525-B2 Reagents for directed biomarker signal amplification RNGTT, CAPG, CA14 RAB9A 3811/4885MAPT 3033/4885SMN1; SMN2 3540/4885
US-12235274-B2 Reagents for directed biomarker signal amplification RNGTT, CAPG, CA14 RAB9A 3811/4885MAPT 3033/4885SMN1; SMN2 3540/4885
US-12345713-B2 Reagents for directed biomarker signal amplification RNGTT, CAPG, CA14 RAB9A 3811/4885MAPT 3033/4885SMN1; SMN2 3540/4885
US-12111321-B2 Reagents for directed biomarker signal amplification RNGTT, CAPG, CA14 RAB9A 3811/4885MAPT 3033/4885SMN1; SMN2 3540/4885
US-12241898-B2 Reagents for directed biomarker signal amplification RNGTT, CAPG, CA14 RAB9A 3811/4885MAPT 3033/4885SMN1; SMN2 3540/4885
US-20260063640-A1 Reagents for Directed Biomarker Signal Amplification RNGTT, RNMT, DNMT3L RAB9A 4250/4885MAPT 1844/4885SMN1; SMN2 856/4885
US-20110256550-A1 Novel reagents for directed biomarker signal amplification RNGTT, CAPG, CD2BP2 RAB9A 3757/4885MAPT 3230/4885SMN1; SMN2 3493/4885
US-12153050-B2 Reagents for directed biomarker signal amplification RNGTT, CAPG, CA14 RAB9A 3811/4885MAPT 3033/4885SMN1; SMN2 3540/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.