Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | DAO | P14920 | 5/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | CCNC | P24863 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18236158 | 0.82 | CREBBP (0.61) | ALDH1A1CREBBPKDM4ENPC1DAO | |
| SCHEMBL8103043 | 0.80 | BAZ2B (0.53) | ALDH1A1CREBBPGAALMNA | |
| SCHEMBL15318227 | 0.80 | HSD17B10 (0.45) | TDP1SMN1; SMN2NOTUMRAB9AALDH1A1 | |
| Hydrochloric Acid SCHEMBL653318 | 0.79 | BAZ2B (0.51) | ALDH1A1CREBBPGAALMNA | |
| SCHEMBL8749077 | 0.77 | TDP1 (0.42) | TDP1SMN1; SMN2NOTUMRAB9ANPC1 | |
| SCHEMBL1337277 | 0.71 | — | — | |
| SCHEMBL874851 | 0.71 | — | — | |
| SCHEMBL14269441 | 0.71 | DAO (0.44) | ALDH1A1CREBBPKDM4ENPC1DAO | |
| SCHEMBL5058082 | 0.70 | NPC1 (0.38) | TDP1SMN1; SMN2RAB9ANPC1HSP90AA1 | |
| SCHEMBL70598 | 0.69 | SMN1; SMN2 (0.62) | TDP1SMN1; SMN2NOTUMRAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080234132-A1 | Microcin B17 Analogs And Methods For Their Preparation And Use | PLANT BIOSCIENCE LIMITED (GB) | 2008-09-25 | — | — | US | disclosed |
| US-6906199-B2 | Process for preparing distamycin derivatives | PHARMACIA ITALIA S.P.A. (IT) | 2005-06-14 | — | — | US | disclosed |
| US-20050014700-A1 | Cbi analogues of cc-1065 and the duocarmycins | SCRIPPS RESEARCH INSTITUTE THE | 2005-01-20 | — | — | US | disclosed |
| EP-1347958-B1 | PROCESS FOR PREPARING DISTAMYCIN DERIVATIVES | PHARMACIA ITALIA SPA (IT) | 2005-01-19 | — | — | EP | disclosed |
| US-20050009054-A1 | Compounds having a fused, bicyclic moiety for binding to the minor groove of dsDNA | PHARMACIA CORPORATION | 2005-01-13 | — | — | US | disclosed |
| WO-2004099131-A2 | COMPOUNDS HAVING A FUSED, BICYCLIC MOIETY FOR BINDING TO THE MINOR GROOVE OF DSDNA | PHARMACIA CORPORATION (US) | 2004-11-18 | — | — | WO | disclosed |
| US-20040077550-A1 | Process for preparing distamycin derivatives | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2004-04-22 | — | — | US | disclosed |
| EP-1347958-A1 | PROCESS FOR PREPARING DISTAMYCIN DERIVATIVES | Pharmacia Italia S.p.A. (IT) | 2003-10-01 | — | — | EP | disclosed |
| US-6566336-B1 | For therapy and prophylaxis of various gene- inducible diseases | JAPAN SCIENCE AND TECHNOLOGY CORPORATION (JP) | 2003-05-20 | — | — | US | disclosed |
| WO-2002044147-A1 | PROCESS FOR PREPARING DISTAMYCIN DERIVATIVES | PHARMACIA ITALIA S.P.A. (IT) | 2002-06-06 | — | — | WO | disclosed |
| EP-0661260-B1 | New bi-aromatic compounds derived from amides pharmaceutical compositions and cosmetic compositions containing them and their use | CIRD GALDERMA (FR) | 1997-03-12 | — | — | EP | disclosed |
| EP-0661260-A1 | New bi-aromatic compounds derived from amides pharmaceutical compositions and cosmetic compositions containing them and their use | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA, ( CIRD GALDERMA) (FR) | 1995-07-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234132-A1 | Microcin B17 Analogs And Methods For Their Preparation And Use | MCM3, MCM7, CCNB3 | TDP1 1687/4885SMN1; SMN2 4080/4885NOTUM 2520/4885 |
| US-20050014700-A1 | Cbi analogues of cc-1065 and the duocarmycins | DCK, CCNI, DDB1 | TDP1 342/4885SMN1; SMN2 3238/4885NOTUM 2771/4885 |
| US-20050009054-A1 | Compounds having a fused, bicyclic moiety for binding to the minor groove of dsDNA | PCNA, POLM, PBRM1 | TDP1 90/4885SMN1; SMN2 3518/4885NOTUM 1466/4885 |
| US-20040077550-A1 | Process for preparing distamycin derivatives | MRPL21, RPN1, HSP90B1 | TDP1 3429/4885SMN1; SMN2 2614/4885NOTUM 4362/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.