Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 | O14649 | 2/20 | 0.62 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 8/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.60 |
| ▸ | NPC1 | O15118 | 6/20 | 0.58 |
| ▸ | RAB9A | P51151 | 6/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | HSPA5 | P11021 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | HSPA9 | P38646 | 1/20 | 0.54 |
| ▸ | HSPA2 | P54652 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | SCD | O00767 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2658062 | 0.88 | NPC1 (0.66) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL995829 | 0.74 | NPC1 (1.00) | KCNK3KCNK9MEN1KMT2ANPC1 | |
| SCHEMBL2628996 | 0.74 | NPC1 (0.76) | KCNK3KCNK9MEN1KMT2ANPC1 | |
| SCHEMBL4285954 | 0.74 | NPC1 (0.85) | KCNK3KCNK9MEN1KMT2ANPC1 | |
| SCHEMBL23011772 | 0.74 | KCNK3 (0.82) | KCNK3KCNK9MEN1KMT2ANPC1 | |
| Hydrochloric Acid SCHEMBL27594584 | 0.73 | NPC1 (0.97) | KCNK3KCNK9MEN1KMT2ANPC1 | |
| SCHEMBL6667286 | 0.73 | ALDH1A1 (1.00) | MEN1KMT2ANPC1RAB9AHTT | |
| SCHEMBL14082925 | 0.72 | NPC1 (0.67) | KCNK3KCNK9MEN1KMT2ANPC1 | |
| SCHEMBL8797071 | 0.72 | NPC1 (0.62) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL8797043 | 0.72 | RAB9A (0.62) | MEN1KMT2ANPC1RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1661563-B1 | Compound effecting Glucokinase | ASTRAZENECA AB (SE) | 2008-05-28 | — | — | EP | claimed |
| EP-1661563-B1 | Compound effecting Glucokinase | ASTRAZENECA AB (SE) | 2008-05-28 | — | — | EP | disclosed |