Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | MMP9 | P14780 | 1/20 | 0.51 |
| ▸ | MMP8 | P22894 | 1/20 | 0.51 |
| ▸ | MMP14 | P50281 | 1/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.49 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.47 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.47 |
| ▸ | PSMB2 | P49721 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL247742 | 0.80 | HSD17B10 (0.63) | ALDH1A1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL249524 | 0.80 | HSD17B10 (0.63) | ALDH1A1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL2672977 | 0.80 | HSD17B10 (0.63) | ALDH1A1KDM4EMEN1KMT2AMAPT | |
| Hydrochloric Acid SCHEMBL4459970 | 0.79 | HSD17B10 (0.61) | ALDH1A1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL9718520 | 0.79 | HSD17B10 (0.61) | ALDH1A1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL17571990 | 0.78 | ALDH1A1 (0.61) | ALDH1A1MEN1KMT2AMAPTHPGD | |
| Alcohol SCHEMBL28032632 | 0.78 | MEN1 (0.64) | ALDH1A1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL4259467 | 0.77 | ADRB2 (0.54) | ALDH1A1KDM4EMEN1KMT2AMAPT | |
| Chloromethane SCHEMBL29855624 | 0.77 | HSD17B10 (0.59) | ALDH1A1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL13232184 | 0.77 | TRPA1 (0.50) | KDM4EMEN1KMT2AMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080305081-A1 | Novel aminopyrimidine derivatives as PLK1 inhibitors | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2008-12-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080305081-A1 | Novel aminopyrimidine derivatives as PLK1 inhibitors | PLK1, AURKA, CDK1 | ALDH1A1 3451/4885KDM4E 1233/4885MEN1 3180/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.